辛伐他汀对高脂血症患者心肌缺血的作用  

Effects of Simvastatin on Exercise-Induced Myocardial Ischemia in Patients with Stable Exertional Angina Pectoris and Hypercholesterolemia

作　　者：霍永佳[1] 陈莺[1] 陈丽[1] 

机构地区：[1]遵义医学院第二附属医院内科,贵阳550002

出　　处：《贵州医药》2005年第9期795-797,共3页Guizhou Medical Journal

摘　　要：目的探讨辛伐他汀调脂治疗对稳定劳力型心绞痛合并高胆固醇血症患者运动诱发心肌缺血的影响。方法选择运动试验阳性且血浆总胆固醇浓度增高的稳定劳力型心绞痛患者90 例,随机分为治疗组和对照组,治疗组给予辛伐他汀12周,对照组仅予饮食控制,治疗前后行心电图运动试验,比较两组运动试验结果的差异。结果(1)经12周治疗后,治疗组血TC、TG、LDL-C均显著降低,HDL-C显著升高(P<0.05),而对照组血脂各项指标的变化均无统计学意义。(2)辛伐他汀组治疗后运动耐量显著提高,运动试验阳性率明显降低,至ST段下移1mm时间明显延长,ST段下移值显著减少(P<0.05),而对照组治疗前后各项指标的变化均无统计学意义。结论辛伐他汀治疗在降低血脂的同时,还可明显减轻稳定劳力型心绞痛合并高胆固醇血症患者运动诱发的心肌缺血。Objective To investigate the effects of simvastatin on myocardial ischemia induced by exercise testing in patients with stable exertional angina pectoris and hypercholesterolemia. Methods Ninety patients with stable exertional angina pectoris, positive exercise test and hypercholesterolemia were randomly divided into a 12-week treatment period either diet plus simvastatin （n=45） or diet a-lone（n=45）. All the patients underwent exercise testing before and after the treatment period. Results （1） Simvastatin-treated patients had a significant reduced in total cholesterol, triglyccrides, high-density lipoprotein cholesterol and low-denslty lipoprotein cholesterol after treatment （P〈0. 05）. （2） After 12 weeks of treatment only 8 patients （18%） in the simvastatin group had a positive exercise test, whereas 41 patients （91%） of the diet group still had positive tests （P〈0. 05）. After treatment, the patients in the simvastatin group had significantly improved in exercise tolerance, prolonged time to ST depression of 1.0mm and reduced the severity of ST depression. Conclusion Simvastatin can reduce exercise-induced myocardial ischemia in patients with stable exertional angina pectoris and hypercholesterolemia.

关 键 词：辛伐他汀 心绞痛 运动试验 

分 类 号：R589.2[医药卫生—内分泌] R972.6[医药卫生—内科学]