双异丙酚对豚鼠、大鼠心室乳头肌机械收缩的影响  

EFFECTS OF PROPOFOL ON CONTRACTIVE ACTIVITIES OF GUINEA-PIG AND RAT PAPILLARY MUSCLES

作　　者：郝永昌 宋立林 郭淑梅 张翼 

出　　处：《河北医科大学学报》1996年第1期4-7,共4页Journal of Hebei Medical University

摘　　要：观察不同浓度双异丙酚对豚鼠、大鼠心室乳头肌收缩活动的影响，并探讨其作用机制。结果表明：①１０μｍｏｌ／Ｌ以上浓度即可明显抑制豚鼠心室乳头肌收缩，使收缩最大张力（Ｐ０）和张力上升最大速率（ｄＴ／ｄｔｍａｘ）分别降至对照值的４３．０％和４５．４％，且呈明显浓度依赖性；但双异丙酚对大鼠心室乳头肌收缩无明显影响，提示双异丙酚对动物心室乳头肌的抑制具有种属差异。②双异丙酚对豚鼠休息后刺激引发的第一次收缩（Ｂ１）和心肌休息后恢复时间（ＲＴ）无明显影响，而对休息后刺激引发的第二次收缩（Ｂ２）有明显抑制作用，提示双异丙酚对豚鼠心室乳头肌的抑制作用可能是通过阻断Ｃａ通道，抑制Ｃａ内流实现的。The effects of Propofol on the contraction of guinea-pig and rat papillary muscle and the underlying mechanism were studied. The results showed that: ①Propofol depressed the contraction of guinea-pig papillary muscle in a dose-dependent manner, the maximum isometric tension (P0) and maximum velocity of tension development (dT/dtmax)were decreased to 43.0% and 45.4% of control, respectively;but had no significant effects on contraction of rat papillary, suggesting that effects of propofol on the contraction of papillary muscle vary with the species of animals. ②Propofol had no significant change on the first postrest beat (B1) and postrest recover time (RT);but had significant decrease on the second postrest beat (B2), suggesting that effects of Propofol on the contraction of guinea-pig papillary muscle could mainly be expressed through the block of Ca channel and the inhibition of transmembrane Ca influx.

关 键 词：麻醉药 双异丙酚 药理实验 心室 乳头肌 鼠 

分 类 号：R971.2[医药卫生—药品] R965.3[医药卫生—药学]