长期饮用不同浓度水氟人群外周血淋巴细胞SCE频率分析  

Fluorides in drinking water and the sister chromatid exchange frequency in human blood lymphocytes

作　　者：梁超轲[1] 吴云鹏[1] 马凤[1] 鲁慧[1] Y.Li B.P.Katz E.J.Brizendine G.K.Stookey 

机构地区：[1]中国预防医学科学院环境卫生与卫生工程研究所,北京100050 [2]美国印第安纳大学牙科医院 [3]美国印第安纳大学医学院

出　　处：《卫生研究》1996年第1期25-28,共4页Journal of Hygiene Research

基　　金：美国NIH/NID-PHS/POI DE-09835研究基金

摘　　要：报道了在正常营养与营养不足状态下,长期接触不同浓度水氟的人群外周血淋巴细胞姊妹染色单体交换(SCE)频率,以评价氟对人群的遗传毒性危险度。调查的人群组分为:0.2、1.0和4.8mg/L三个不同的饮水氟水平,每一组水氟浓度又分为正常营养与营养不足两组,共6个组。这些农民长期居住于该地区并饮用该氟浓度的水,年龄为40岁以上。结果表明,高浓度水氟未引起人群SCE频率增加,即本研究未发现氟的遗传毒性作用。The purpose of this investigation was to determine genotoxic risks of long-term exposure to various concentrations of fluorides in drinking water in humans with normal or inadequate nutrition. Six groups of subjects with either normal or inadequate nutritional intakes were selected from areas of 0. 2,1.0 and 4.8 mg/L fluoride in drinking water. The subjects with average age of 46 years were local residents in these areas. Blood lymphocytes were examined to determine the frequency of sister chromatid exchange (SCE). The daily fluoride intake increased with the increase in the fluoride content of drinking water. The results demonstrated that long-term exposure to fluoride drinking water, even at an elevated level, does not increase the SCE frequency. The authors conclude that fluorides have no genotoxic effects in humans.

关 键 词：饮用水 氟浓度 遗传毒性 淋巴细胞 

分 类 号：X520.31[环境科学与工程—环境工程] R994.6[医药卫生—毒理学]