蛋白质组学及其在重离子治癌应用中的探讨  

Research of Proteomics and Its Application in Tumour Treatment by Heavy Ion

作　　者：邴涛 谢漪[1,2] 党秉荣 杨媛[4] 李文建[3] 张红[3] 

机构地区：[1]中国科学院研究生院 [2]中国科学院近代物理研究所,甘肃兰州730000 [3]中国科学院近代物理研究所 [4]兰州大学生命科学院

出　　处：《原子核物理评论》2005年第3期292-295,共4页Nuclear Physics Review

基　　金：中国科学院西部之光基金资助项目(XB040602);甘肃省青年科学基金资助项目~~

摘　　要：综述了蛋白质组学的主要方法和技术———双向凝胶电泳、生物质谱技术、蛋白质芯片技术,及其在肿瘤标志物的筛选和鉴定、肿瘤治疗效果的评价及肿瘤发生机制研究等方面的应用状况,并对蛋白质组学在重离子治疗中的应用进行了展望。With the accomplishment of the human genome project, proteomics becomes a new snbject on the buildup of the whole proteins and their dynamic changes in cell emerges. Cancer is a kind of complex disease involved in multi-genes and proteins. Heavy ion therapy is all arising and potential radiation treatment nowadays. This paper reviews on the main methods and technology in proteomics-- two-dimensional gel electrophoresis （2-DE）, biological mass spectrometry, protein biochips, bioinformatics and its application on identification of cancer biomarkers, evaluation of curative effect on tumour and the mechanisms of turnout formation. This paper also presents some prospects on the application of proteomics in heavv ion therapy.

关 键 词：蛋白质组学 重离子治疗 癌症 

分 类 号：Q71[生物学—分子生物学] Q691