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机构地区:[1]上海第二医科大学附属新华医院呼吸科,上海200092
出 处:《中国临床医学》2005年第4期590-591,共2页Chinese Journal of Clinical Medicine
摘 要:目的:探讨BiPAP呼吸机治疗慢性阻塞性肺病(COPD)合并睡眠呼吸障碍综合征(SAS)临床疗效。方法:用BiPAP呼吸机治疗42例COPD合并SAS患者2周,比较治疗前后患者总睡眠时间(TST)、呼吸紊乱指数(RDI)、夜间最低氯饱和度(SaO2Low)、pH、PaO2和PaCO2的变化。结果:治疗前患者总睡眠时间(TST)、呼吸紊乱指数(RDI)、夜间最低氧饱和度(SaO2Low)、pH、PaO2分别为(371.29±57.80)min,(9.44±6.78),(79±15.72)%,(7.28±0.05),(6.21±1.32)kPat治疗后TST,RDI,SaO2Low,pH,PaO2分别为:(400.57±62.13)min,(7.31±4.26),(87±7.37)%,(7.38±0.04),(8.67±1.26)kPa.较治疗前有显著改善(P<0.01)。结论:Bi-PAP呼吸机在提高患者的总睡眠时间、SaO2、PaO2,降低呼吸紊乱指数方面疗效显著,是无创性治疗COPD合并睡眠呼吸障碍综合征的有效措施。Objective: To explore the clinical effect of BiPAP ventilator in treatment of chronic obstructive pulmonary disease (COPD) with sleep apnea syndromes(SAS). Methods: Forty-two patients with chronic obstructive pulmonary disease (COPD) who suffered from sleep apnea syndromes have been treated with BiPAP ventilator for two weeks. Total sleep time (TST), respiratory disorder index (RDI), the lowest SaO2 (SaO2B), pH, and PaO2 were monitored before and after treatment. Results: TST, RDI, SaO2B, pH, and PaO2 of the protreated group were (371.29±57. 80)min , (9. 44±6. 78), (79±15. 72)%, (7. 28±0. 05 ), (6. 21±1.32) kPa, respectively; Those of post-treated group were (400.57±62. 13)min, (7. 31±4. 26), (87±7. 37) %, (7. 38±0. 04), and (8. 67±1.26) kPa, respectively, There was significant different between two group (P〈0. 01 ). Conclusion: BiPAP ventilator may have a great effect on improvement of TST, SaO2B, pH, PaO2 and decrement of RDI, which is an effective method in noninvasive treatment of COPD with sleep apnea syndromes.
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