四种有机磷毒剂对人脑乙酰胆碱酯酶抑制作用的计算机模拟研究  

Computer simulation of the inhibitory action of four organophosphorus toxic agents on human brain acetylcholinesterase

作　　者：焦克芳[1] 李松[1] 鲁中正 

机构地区：[1]军事医学科学院毒物药物研究所

出　　处：《中国药理学与毒理学杂志》1996年第1期67-70,共4页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金

摘　　要：本文在预测中毒乙酰胆碱酯酶三维空间结构的基础上，提出部分结构参量，讨论其可能的中毒，老化及其重活化差异等机理。On the basis of the three dimensional structure of human brain acetylcholinesterase (hAChE), the mechanism of intoxication of hAChE by four organophosphorus poisons (sarin, soman, tabun and Vx) was studied. We suggested that the distance between the main interacting atoms of the toxic agent and hAChE active site might be used to measure the strength of action between toxic agent and hAChE. Some differences of the aging of AChE P and differences of the reactivating of AChE P were discussed as well.

关 键 词：有机磷毒剂 胆碱酯酶 神经性毒剂 计算机模拟 

分 类 号：R827.172[医药卫生—临床医学] R992