阿奇霉素与头孢克肟治疗小儿细菌性腹泻病疗效比较  

Comparison of Azithromycin versus Cefixime for Treatment of Bacterial Diarrhea in Children.

作　　者：王希华[1] 周莎[1] 蔡虹蔚[1] 

机构地区：[1]上海第二医科大学附属新华医院

出　　处：《中国临床医学》2005年第4期724-725,728,共3页Chinese Journal of Clinical Medicine

摘　　要：目的:评价阿奇霉素对小儿细菌性腹泻病的疗效,并与头孢克肟的治疗效果进行比较。方法:病例选择:2004年7月-11月间我院肠道门诊急性腹泻患儿,共121例,每日腹泻次数≥3次,大便常规镜检白细胞≥10/HP;未用过抗生素,或使用其它抗生素无效。年龄4个月-12岁。阿奇霉素10mg·kg-1,每日1次口服,共64例;头孢克肟5-8mg·kg-1·d-1,分2次口服,共57例。治疗72h判断疗效。结果:阿奇霉素治疗组,显效68.75%(44/64),有效29.69%(19/64),无效1.56%(1/64),总有效率98.44%。头孢克肟治疗组57例,显效64.91%(37/57),有效31.58%(18/57);无效3.51%(2/57);总有效率96.49%。两组疗效无显著差异(X2=0.472,P>0.05)。结论:阿奇霉素治疗小儿细菌性腹泻病临床疗效显著,可选择作为治疗小儿细菌性腹泻病的药物。Objective： To evaluate and compare the efficacy of azithromycin and cefixime in the treatment of acute bacterial invasive diarrhea in children. Methods： From Jul. 2004 to Nov. 2004, 121 evaluable children ,ages 4 months to 12 years old presenting with acute bacterial diarrhea were randomized to receive either azithromycin （10 mg/kg/day, once a day ; n = 64） or cefixime （5-8 mg/kg/day ,twice a day; n = 57）. Clinical response were assessed on days 3. Results： Clinical cure or improvement was observed in 98. 44% and 96.49% of the azithromycin and cefixime groups, respectively. There was no significant difference between two groups（x^2 = 0. 472, P〉0. 05）. Conclusion：Oral azithromycin was safe and effective for the empiric treatment of acute invasive diarrhea in pediatric patients.

关 键 词：阿奇霉素 头孢克肟 细菌性腹泻病 儿童 

分 类 号：R725[医药卫生—儿科]