间硝苯地平的生物利用度  

Bioavailability of m nifedipine in rabbits

作　　者：马骏[1,2] 许顺尧 宋岭[1,2] 蒋永培[1,2] 赵德化[1,2] 

机构地区：[1]第四军医大学药理学教研室 [2]第四军医大学西京医院药剂科

出　　处：《第四军医大学学报》1996年第1期36-38,共3页Journal of the Fourth Military Medical University

摘　　要：目的：研究间硝苯地平在兔体内的生物利用度．方法：在清醒兔静脉注射（１ｍｇｋｇ－１）和灌胃（ｉｇ）给（４ｍｇｋｇ－１）间硝苯地平，不同时间采血，测定血药浓度．结果：间硝苯地平的血药浓度时间数据经计算机程序拟合，ｉｇ给药符合一房室模型而静脉注射符合二室模型；其绝对生物利用度为３１．８％．结论：间硝苯地平在兔体内的绝对生物利用度较低．Objective: To study the bioavailability of m nifedipine in conscious rabbits. Methods: Intravenous injection and ig administration of m nifedipine were applied to two groups of rabbits. Results: The pharmacokinetics of m nifedipine conformed to the one compartment model in ig administration and the two compartment model in intravenous injection. The absolute bioavailability was 31.82%. Conclusion: The present study suggests that the absolute bioavailability of m nifedipine in rabbits is relatively low.

关 键 词：间硝苯地平 药物代谢动力学 生物利用度 

分 类 号：R972[医药卫生—药品] R969.1[医药卫生—药学]