比索洛尔与阿替洛尔治疗轻、中度高血压的疗效比较  

Comparison the Efficacy of Bisoprolol and Atenolol in the Treatment of Mild to Moderate Essential Hypertension

作　　者：金翠燕[1] 王宪衍[1] 钱珠[1] 董寿祺[1] 

机构地区：[1]上海第二医科大学附属瑞金医院,上海市高血压研究所

出　　处：《上海第二医科大学学报》1996年第1期17-19,共3页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：口服比索洛尔（５～２０ｍｇ／ｄ）与阿替洛尔（２５～１００ｍｇ／ｄ）对１２０例原发性高血压患者进行对比研究，结果显示：比索洛尔总有效率８８．６％，阿替洛尔总有效率８３．６％，两组疗效无明显差异（Ｐ＞０．０５）。不良反应主要为心动过缓，血常规、肝、肾功能、血脂、血电解质、血糖、血尿酸等均无不良影响。比索洛尔作用时间长，平均有效剂量为９．５～１２．９ｍｇ／ｄ，每日只需服１次，病人服用方便，研究表明，比索洛尔治疗轻、中度高血压安全、有效。The effect of Bisoprolol (5-20mg/d) was compared with that of Atenolol (25-100mg/d)in 120 patients with essential hypertension. Results showed that the total effective rate of Bisoprolol and Atenolol were 88.6% and 83.6%, respectively. No statistically significant difference was abserved between these drugs (p>0.05).The main adverse reaction was bradycardia. There was no abnormal laboratory finding during treatment. The Bisoprolol had a long elimination half-life which allows once-daily administration.The effective dosage of Bisoprolol was 10-12 mg/d. It is concluded the Bisoprolol is an effective, safe and well tolerated antihypertension agent for patients of mild to moderate hypertension.

关 键 词：高血压 比索洛尔 阿替洛尔 疗效 

分 类 号：R544.105[医药卫生—心血管疾病] R972.4[医药卫生—内科学]