4-(2-苄氧基乙氧基羰基)氧杂环丁-2-酮的合成及表征  

Synthesis and Characterization of 4-(2-Benzyloxy-ethoxycarbonyl)-2-oxetanone

作　　者：王亮[1] 贾小华[1] 袁直[1] 

机构地区：[1]南开大学高分子化学研究所,天津300071

出　　处：《高等学校化学学报》2005年第9期1650-1652,共3页Chemical Journal of Chinese Universities

基　　金：教育部南开大学-天津大学科技合作基金;吸附分离国家重点实验室开放基金资助

摘　　要：4-(2-Benzyloxyethoxycarbonyl)-2-oxetanone, an β-substituted-β-lactones with latent pendent hydroxyl groups,was synthesized from L-aspartic acid. Firstly, bromosuccinic acid was synthesized from L-aspartic acid and it was dehydrated to bromosuccinic anhydride by TFFA. Then the anhydride was alcoholysized to the monoester mixture by 2-benzyloxy ethanol. Finally, the novel monomer was got through a intromolecular cyclization of the mixture ester, and then it was further purified by silicon gel chromatogram. The product and the intermediates were characterized by {{}+1H NMR}, {}+{13}C NMR and elemental analysis. In addition, 2-benzyloxy ethanol was synthesized with a simplyified procedure and high yield by using Williamson method.4-（2-Benzyloxyethoxycarbonyl）-2-oxetanone, an β-substituted-β-1actones with latent pendent hydroxyl groups, was synthesized from L-aspartie acid. Firstly, bromosueeinie acid was synthesized from L-aspartic acid and it was dehydrated to bromosueeinie anhydride by TFFA. Then the anhydride was aleoholysized to the monoester mixture by 2-benzyloxy ethanol. Finally, the novel monomer was got through a intromoleeular eyelization of the mixture ester, and then it was further purified by silicon gel ehromatogram. The product and the intermediates were characterized by ^1H NMR, ^13C NMR and elemental analysis. In addition, 2-benzyloxy ethanol was synthesized with a simplyified procedure and high yield by using Williamson method.

关 键 词：2-苄氧基乙醇 溴代丁二酸 4-(2-苄氧基乙氧基羰基)氧杂环丁-2-酮 

分 类 号：O631[理学—高分子化学]