溶胶-凝胶法原位复合PVA/HA水凝胶的结构表征与性能研究  

Characterization and Properties of Poly(vinyl alcohol)/Hydroxylapatite Hydrogels Prepared by Compound in situ with Sol-gel Method

作　　者：郑裕东[1] 王迎军[2] 陈晓峰[2] 刘青[2] 吴刚[2] 

机构地区：[1]北京科技大学材料科学与工程学院,北京100083 [2]广州华南理工大学材料科学与工程学院,广州510640

出　　处：《高等学校化学学报》2005年第9期1735-1738,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:59932050);广东省自然科学基金(批准号:990621);广东省重点科技攻关项目(批准号:A302020202);北京科技大学科研基金资助.

摘　　要：采用溶胶-凝胶原位复合的方法制备了聚乙烯醇/羟基磷灰石生物活性复合水凝胶,探讨了HA含量对复合水凝胶结构性能的影响,用X射线衍射分析、红外光谱分析、DSC、扫描电镜等方法对HA在PVA水凝胶体系中的晶态结构及分散状态进行了表征,并与物理共混复合法进行了比较.研究发现,采用溶胶-凝胶法原位复合可在PVA水凝胶中形成具有生物活性的HA结晶结构,且分散良好,分布均匀.HA粉体作为异相成核剂,促进了PVA水凝胶基体的结晶,提高了复合水凝胶的力学性能.A new kind of bioactive polyvinyl alcohol （PVA）/ hydroxylapatite （HA） blend hydrogels were prepared by compound in situ with sol-gel synthesis of HA. The structures and properties of the blend hydrogels with different HA contents were investigated. The crystal structure and dispersed statement of HA in hydrogels were characterized by XRD, FTIR and SEM. PVA/HA, hydrogels were also prepared by physical mixing as a comparison. Ultrafine granular-crystaUine HA powder was formed in blend hydrogels with sol-gel synthesis of HA in situ when compounding with PVA solution. Whereas HA was dispersed hon-uniformly and formed agglomeration of HA powder in blend hydrogels when compoumding with PVA by physical mixing. As a additional crystal core, HA accelerated the crystallization of PVA hydrogels, and increased the mechanical strength of the blend hydrogels.

关 键 词：水凝胶 聚乙烯醇 羟基磷灰石 生物活性 

分 类 号：O631[理学—高分子化学]