电活性可生物降解材料聚乳酸与苯胺五聚体嵌段共聚物的合成与表征  

Synthesis and Characterization of Electro-active and Biodegradable Block Copolymer of Aniline Pentamer with Polylactide

作　　者：黄利红[1] 胡军[1] 庄秀丽[1] 马嘉[1] 陈学思[1] 景遐斌[1] 郭毅[2] 李梦燕[2] Peter I.Lelkes 危岩[2] 

机构地区：[1]中国科学院长春应用化学研究所高分子物理与化学国家重点实验室 [2]爵硕大学化学系

出　　处：《高等学校化学学报》2005年第9期1771-1773,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:50273038;20274028);国家杰出青年基金(批准号:50425309)资助.

摘　　要：Every slight movement of human body, such as beat of heart, contract of muscles, thinking of brain, is associated with bioelectricity. In search for a neural conducting tissue engineering material which can {ideally} conduct bioelectrical signals in vivo, the block copolymer of polylactide(PLA) and aniline pentamera material which is electro-active, remarkably biocompatible and biodegradable, was designed and synthesized. The aniline pentamer is similar with polyaniline in electrical chemical properties, but more soluble than the latter. The copolymer is prepared by condensation polymerization between carboxyl-capped aniline pentamer and {dihydroxyl}-capped PLA, with N,N′-dicyclohexylcarbodiimide(DCC) as a condensing agent. The co-polymerization of aniline pentamer and PLA can not only reduce the toxicity of aniline pentamer, but also make the {material} easily to degrade and excrete from the body. These properties of the copolymer provide a favorable prospect in biomedical application in vivo. The synthesized material is investigated by FTIR, {}+1H NMR, UV, and cyclic voltammetric measurements.Every slight movement of human body, such as beat of heart, contract of muscles, thinking of brain, is associated with bioelectricity. In search for a neural conducting tissue engineering material which can ideally conduct bioelectrical signals in vivo, the block copolymer of polylactide （PLA） and aniline pentamer——a material which is electro-active, remarkably biocompatible and biodegradable, was designed and synthesized. The aniline pentamer is similar with polyaniline in electrical chemical properties, but more soluble than the latter. The copolymer is prepared by condensation polymerization between carbexyl-capped aniline pentamer and dihydroxyl-capped PLA, with N, N＇-dicyclohexylcarbodiimide （DCC） as a condensing agent. The co-polymerization of aniline pentamer and PLA can not only reduce the toxicity of aniline pentamer, but also make the material easily to degrade and excrete from the body. These properties of the copolymer provide a favorable prospect in biomedical application in vivo. The synthesized material is investigated by FTIR, ^1H NMB,UV, and cyclic voltammetric measurements.

关 键 词：聚乳酸 苯胺齐聚物 电活性 可生物降解 

分 类 号：O631[理学—高分子化学]