悬雍垂腭咽成形术后患者胰岛素抵抗观察  

Effects of surgical treatment on insulin resistance in obstructive sleep apnea hypopnea syndrome patients

作　　者：史视明[1] 赵国峰[2] 王东海[2] 

机构地区：[1]河北省唐山市协和医院内分泌科,河北唐山063000 [2]河北省唐山市协和医院耳鼻咽喉科,河北唐山063000

出　　处：《中国耳鼻咽喉头颈外科》2005年第8期529-531,共3页Chinese Archives of Otolaryngology-Head and Neck Surgery

摘　　要：目的探讨阻塞性睡眠呼吸暂停低通气综合征(obstructivesleepapneahypopneasyndrome,OSAHS)患者采用悬雍垂腭咽成形术(uvulopalato-pharyngoplasty,UPPP)治疗前后胰岛素抵抗情况的变化。方法中及重度OSAHS43例,采用UPPP治疗,观察手术前后体重指数、血压、空腹血糖、空腹胰岛素、糖化血红蛋白、餐后2小时血糖、HOMA法胰岛素抵抗指数(HOMA-IR)的变化。结果UPPP治疗3个月后,血氧饱和度(oxygensaturation,SaO2)明显升高,睡眠呼吸暂停低通气指数(apneahypopneaindex,AHI)降低,收缩压明显下降,血糖、胰岛素抵抗指数轻度下降;OSAHS合并糖尿病患者胰岛素用量明显减少;体重指数无明显变化。结论OSAHS患者UPPP治疗后,从HOMA-IR、空腹胰岛素、空腹血糖、胰岛素用量、血压等多方面反应胰岛素抵抗好转。OBJECTIVE To investigate the effects uvulopalatopharyngoplasty （UPPP）on insulin resistance in obstructive sleep apnea hypopnea syndrome （OSAHS） patients. METHODS Forty three cases of OSAHS treated with UPPP, were assayed for BMI, blood pressure, serum glucose （fasting and 2-hour postprandial）, fasting serum inslin, HbA1Cand HOMA-IR. RESULTS The result showed, after surgical, the level of serum glucose, HOMA-IR were decreased in OSAHS with non-diabetes; the insulin dose in OSAHS with diabetes were decreased. CONCLUSION The study confirms that insulin resistance were decreased in OSAHS treated with UPPP.

关 键 词：睡眠呼吸暂停 阻塞性 悬雍垂 腭 软 外科手术 胰岛素抵抗 胰岛素抵抗指数 悬雍垂腭咽成形术 术后患者 阻塞性睡眠呼吸暂停低通气综合征 

分 类 号：R766[医药卫生—耳鼻咽喉科]