冰片滴鼻对豚鼠鼻粘膜血管和脑血管通透性的影响研究  

Study on the Effect of Borneol Nasal Drops on the Vasopermeability of Nasal Mucosa and Cerebral Vessel of Guinea Pigs

作　　者：张瑞涛[1] 王晖[1] 陈丽[1] 李昕[1] 

机构地区：[1]广东医学院药理学教研室,湛江市524023

出　　处：《中国药房》2005年第17期1291-1293,共3页China Pharmacy

基　　金：广东省中医药管理局资助课题(102086)

摘　　要：目的:研究不同浓度冰片滴鼻后对豚鼠鼻粘膜血管和脑血管通透性的影响。方法:将豚鼠随机分为系列浓度冰片(0.5%、1.0%、2.0%)组、组胺组和液体石蜡组,滴鼻给药后静脉注射2%伊文思蓝(EB),10min后处死豚鼠,取鼻粘膜和脑组织,测定并计算鼻粘膜和脑组织中EB含量。结果:与液体石蜡组比较,系列浓度冰片组鼻粘膜和脑组织中EB含量更高(P<0.05或P<0.01),并以2.0%冰片组最为明显。结论:冰片滴鼻可以明显增加豚鼠鼻粘膜血管和脑血管的通透性。OBJECTIVE： To observe the effect of different concentration of borneol nasal drops on the vasopermeability of nasal mucosa and the cerebral vessels. METHODS： Guinea pigs were divided into 5 groups, i .e. borneol group in 3 different concentrations（0.5%, 1.0% and 2.0% ）, histamine group and liquid paraffin group. Guinea pigs were injected i.v with 2% evans blue（EB） after administration with nasal drops, which were then put to death 10min later; the nasal mucosa and brain tissue of which were obtained and the EB contents in which were determined. RESULTS： Compared with the liquid paraffin group, the EB contents in the nasal mucosa and brain tissue in the borneol groups were higher（P〈0.05 or P〈0.01） with the 2.0% borneol group the highest. CONCLUSION： Borneol nasal drops can obviously increase the vasopermeability of nasal mucosa and the cerebral vessels.

关 键 词：冰片 滴鼻 鼻粘膜血管 脑血管 通透性 

分 类 号：R285.5[医药卫生—中药学]