氟尿嘧啶经豚鼠动脉、静脉与腹腔给药后的血药浓度变化  

Study on the Blood Concentration of Fluorouracil Administered into Guinea Pigs by Arterial&Intravenous Infusion and Celiac Infusion

作　　者：陈榕[1] 周学琴[1] 郭长杰[1] 

机构地区：[1]北京大学深圳医院药剂科,深圳市518036

出　　处：《中国药房》2005年第17期1297-1299,共3页China Pharmacy

摘　　要：目的:比较和分析豚鼠经不同途径给予氟尿嘧啶后血药浓度的变化。方法:豚鼠分别经动脉输注(A组)、静脉输注(B组)、腹腔灌注(C组)3种途径给予氟尿嘧啶后分别采集不同时间外周静脉和门静脉血样品,应用高效液相色谱法检测并分析血药浓度及其变化。结果:给药后,A、B组门静脉和外周静脉血药浓度5min达峰值,C组10min达峰值;A组门静脉血药浓度于前20min时为最高值,C组在后30min时浓度最高。结论:在局部化疗情况下,宜选择“动脉输注联合腹腔灌注”给药方式;在局部化疗兼顾全身化疗情况下,宜选择“动、静脉联合输注”或“静脉输注联合腹腔灌注”给药方式。OBJECTIVE： To compare and analyze blood concentration changes of fluorouracil administered to guinea pigs by different paths. METHODS： The peripheral vein and portal vein blood samples of guinea pigs were taken at different time after administered with fluorouracil in 3 different ways： group A （by arterial infusion）, group B （by intravenous infusion） and group C （by celiac infusion） . The blood concentration changes were determined and analyzed by HPLC. RESULTS： The portal vein and peripheral vein blood concentrations in group A and B reached peak value 5 min after administration with fluorouracil while group C reached peak at 10 min; the portal vein blood concentrations in group A reached the highest in the first 20 min while group C showed the highest value in the last 30 min. CONCLUSION： Arterial infusion combining celiac infusion path was recommended for local chemotherapy; arterial infusion combining intravenous infusion or intravenous infusion combining celiac infusion was recommended for the local therapy while giving consideration to systemic chemotherapy.

关 键 词：动脉输注 静脉输注 腹腔灌注 血药浓度 

分 类 号：R969.1[医药卫生—药理学] R979.1[医药卫生—药学]