非离子表面活性剂囊泡对头孢菌素药物的缓释作用  

Slower Release of Cephalosporin Drugs in Niosomes of Nonionic Surfactant

作　　者：杜美菊[1] 王亚婷[2] 赵凤林[2] 李娜[2] 李克安[2] 

机构地区：[1]河南省商丘师范学院化学系,河南商丘476000 [2]北京大学化学与分子工程学院,北京100871

出　　处：《化学研究》2005年第3期67-70,共4页Chemical Research

摘　　要：用超声法制备了Span系列非离子表面活性剂囊泡,研究了它们对几种水溶性头孢菌素药物的包封作用及影响包封率的因素,通过透射电镜对囊泡的形态和大小进行了鉴定.实验表明,制得的囊泡多为球形单室囊泡,且包封后的药物在模拟肠液和模拟胃液中均有缓释作用.Niosomes from a series of nonionic surfactants of Span were prepared by sonication method. The entrapment behavior of the as-prepared niosomes for some water-soluble cephalosporin drugs and the factors which affect the entrapment efficiency were investigated. TEM was used to characterize the morphology and size of the niosome. The results show that the niosomes are mainly spherical in shape. In simulated gastric and intestinal fluid, a slow release rate of the entrapped drugs was observed.

关 键 词：非离子表面活性剂 囊泡 药物载体 SPAN 头孢菌素 

分 类 号：O647.2[理学—物理化学]