三维适形脾区放疗与药物治疗慢性特发性血小板减少性紫癜疗效比较  

The efficacy of splenic three dimensional conformal radiation therapy on chronic idiopathic thrombocytopenic purpura

作　　者：任宝志[1] 韩磊[1] 冯长伟[2] 山长平[1] 朱培军[1] 

机构地区：[1]济宁医学院附属医院肿瘤科,山东济宁272029 [2]济宁医学院附属医院血液科

出　　处：《临床血液学杂志》2005年第5期279-280,共2页Journal of Clinical Hematology

摘　　要：目的:对比分析三维适形脾区放疗与药物治疗对慢性特发性血小板减少性紫癜(CITP)的疗效、不良反应及预后。方法:将60例脾区放射指数较高的CITP患者随机分为2组:三维放疗组(30例)经CT定位、三维适形照射,每次1.8Gy,每周5次,总剂量为30.6Gy;药物治疗组(30例)口服泼尼松30～60mg/d,有效后逐渐减量,再用小剂量维持治疗。结果:三维放疗组与药物治疗组的总有效率分别为87.0%和73.0%,2组疗效比较差异无统计学意义(P>0.05)。结论:三维适形脾区放疗的疗效高,不良反应小,与药物治疗的疗效相当,可成为脾区放射指数较高CITP患者的首选疗法之一,亦可成为脾动脉栓塞复发后的补救治疗。Objective： To analyse the effects of three dimensional conformal radiation therapy （3DCRT） on spleen for the treatment of chronic idiopathic thrombocytopenic purpura （CITP）. Method： Sixty cases with CITP were randomly divided into two groups： 3DCRT group were treated by 3DCRT to a dose about 30.6 Gy/17f·23d^-1 （1.8 Gy/f, 5 f/week）; medication group were treated with prednisone （30～60 mg/d ）. Result： The efficient rates of 3DCRT group were 73%, 9 cases （30%） was curative. There were no differences of efficient rates be tween the two groups. Conclusion：3DCRT on spleen is one of the best treatment for CITP; if the radiative index of the spleen is high, 3DCRT on spleen can replace the surgical and splenic embolism＇s treatment for CITP.

关 键 词：紫癜 特发性血小板减少性 脾脏 放疗 预后 

分 类 号：R554[医药卫生—血液循环系统疾病]