MDMA在急性中毒大鼠体内的分布研究  

DISTRIBUTION OF MDMA IN ACUTE POISONED RATS

作　　者：张蕾萍[1] 王玉瑾[1] 貟克明[1] 安健康[1] 王英元[1] 

机构地区：[1]山西医科大学法医学院,太原030001

出　　处：《中国药物依赖性杂志》2005年第4期254-257,共4页Chinese Journal of Drug Dependence

基　　金：山西省自然科学基金资助项目(20011066);山西省教委开发项目(编号:20041319)

摘　　要：目的:建立3,4-亚甲基二氧基甲基苯丙胺(MDMA)大鼠急性中毒模型,研究MDMA在大鼠体内的分布情况。方法:按30mg·kg-1给予实验大鼠MDMA盐溶液,灌胃(ig),2h后脱臼处死。运用乙醚萃取衍生化法和气/质联用技术(GC/MS),对大鼠体内各组织和血液中的MDMA进行定性定量分析。结果:急性中毒大鼠体内各组织和血液中MDMA浓度大小依次是:脾>胃>肺>肝>肾>脑>心肌>心血。结论:MDMA广泛分布于大鼠体内各组织及血液中,对这些组织均有潜在的毒害。Objective： To develop a model of acute 3,4-methylenedioxymethamphetamine （MDMA） poisoned rats and study its distribution in rats. Methods： Rats were administered with MDMA solutions （30 mg·kg^-1, ig） to set up acute MDMA poisoned animal model, then killed 2 hours later. Specimens were extracted by ether and derived with trifluoroacetic, and the level of MDMA in tissues and blood of rats was determined with gas chromatography/mass spectrumetry（GC/MS）. Results： The order of concentration of MDMA in tissues and blood of the acute poisoned rats was as follows： spleen〉stomach〉lung〉liver〉kidney〉brain〉myocardium〉cardiac blood. Conclusion： MDMA is distributed broadly in tissues and blood of acute poisoned rats, showing potential damage to these tissues.

关 键 词：3 4-亚甲基二氧基甲基苯丙胺(MDMA) 气/质联用 分布 实验大鼠 MDMA 急性中毒 体内 气/质联用技术 定性定量分析 甲基苯丙胺 

分 类 号：R961[医药卫生—药理学] R996[医药卫生—药学]