IL-7对中国HIV/AIDS患者病程的影响  

Effects of interleukin-7 on disease progression in HIV/AIDS patients from China

作　　者：王琪[1] 尚红[1] 姜拥军[1] 王亚男[1] 韩晓旭[1] 张子宁[1] 刘静[1] 

机构地区：[1]中国医科大学附属第一医院艾滋病研究所,沈阳110001

出　　处：《中华微生物学和免疫学杂志》2005年第8期667-671,共5页Chinese Journal of Microbiology and Immunology

基　　金：国家十五科技攻关课题(2004BA719A12)

摘　　要：目的了解IL7对中国HIVAIDS患者病程的影响。方法应用超敏感酶免法对66例中国HIVAIDS感染者及8例健康对照者血浆IL7水平进行定量检测,分析其与CD4+T细胞绝对值、血浆病毒载量及HIV表型的相关性;并且在体外研究rhIL7对人PBMC中T淋巴细胞增殖及CXCR4表达的影响。结果中国HIVAIDS患者血浆IL7水平高于健康对照(P<0.05),与CD4+T细胞绝对值负相关(P<0.01),与血浆病毒载量正相关(P<0.05)。rhIL7可在体外促进T淋巴细胞增殖反应及CXCR4表达。结论中国HIVAIDS患者血浆IL7水平升高,且与疾病进展密切相关,可作为疾病进展的相关标志之一。Objective To investigate the effects of IL-7 on disease progression in HIV/AIDS patients. Methods Plasma IL-7 levels of 66 HIV/AIDS patients and 8 healthy controls were determined by an ultrasensitive ELISA, its relations with CD4^＋ T cells, plasma viral load and HIV phenotypes were analysed. T lymphocyte proliferation and CXCR4 expression of peripheral blood mononuclear cells from healthy donors were cocultured with rhIL-7, followed by flow cytometry. Results Significant high level IL-7 was found in HIV/AIDS patients（ P〈0.05）, IL-7 level was negatively correlated with CD^4＋ T cell absolute count（P〈0.01） and positively correlated with plasma viral load （P〈0.05） . Conclusion rhIL-7 may induce T lymphocyte proliferation and up-regulate CXCR4 exoression in vitro, so IL-7 plasma level may be function as a potential marker of HIV disease progression.

关 键 词：人类免疫缺陷病毒-1(HIV-1) 白细胞介素-7(IL-7) HIV/AIDS患者 IL-7 中国 T淋巴细胞增殖反应 病程 血浆病毒载量 CD4^+T细胞 CD^+T细胞 

分 类 号：R512.91[医药卫生—内科学] R739.502[医药卫生—临床医学]