羟丙基-β-环糊精对隐丹参酮的增溶作用及其包合物的制备  

Solubilization on cryptotanshinone by hydroxypropyl-β-cyclodextrin and preparation of their inclusion compound

作　　者：罗昕[1] 徐月红[1] 陈宝[1] 古练权[1] 黄民[1] 刘培庆[1] 

机构地区：[1]中山大学药学院,广东广州510080

出　　处：《中国中药杂志》2005年第17期1328-1331,共4页China Journal of Chinese Materia Medica

摘　　要：目的:制备隐丹参酮-环糊精包合物,提高隐丹参酮(CT)的溶出度。方法:绘制CT-羟丙基-β-环糊精(HPCD)相溶解度曲线,以确定包合比例;采用湿研磨法制备隐丹参酮-环糊精包合物;利用体外溶出度、差热分析、红外光谱等方法研究包合物的性质。结果:CT与HPCD的包合比例为1∶1,CT-HPCD包合物在45 min的溶出度可达到原料药的21.6倍。结论:包合物能显著提高CT的溶出度,包合物包结作用的热力学键力是CT分子的羰基与HPCD分子的羟基形成氢键。Objective： To prepare cryptotanshinone（CT）-cyclodextrin inclusion compound and improve dissolution of CT. Method： Inclusion ratio was detemained by plotting the phase solubility curve of CT versus hydroxypropyl-β-cyclodextrin （HPCD）. CT-cyclodextrin inclusion compound was made by wet grinding method. Properties of the inclusion compound was investigated by in vitro dissolution test, DTA and IR spectnun. Result： Inclusion ratio of CT versus HPCD was 1： 1. Dissolution of CT-HPCD inclusion compound at 45 min was 21.6 times of material drug. Conclusion： Dissolution of CT was improved remarkably in CT-HPCD inclusion compound. The complexation force of the inclusion compound was hydrogen bond formed by carbonyl group of CT and hydroxyl group of HPCD.

关 键 词：隐丹参酮 羟丙基-Β-环糊精 包合物 溶出度 

分 类 号：TQ461[化学工程—制药化工]