紫金散对H22小鼠肝癌实体瘤及腹水瘤抑瘤率的实验研究  

Zijin powder in inhibiting H22 mice solid and ascites liver cancer: experimental study

作　　者：韦大文[1] 贾玉梅[1] 李中正[2] 

机构地区：[1]河南中医学院,河南郑州450008 [2]山东中医药大学,山东济南250014

出　　处：《中国中药杂志》2005年第17期1346-1348,共3页China Journal of Chinese Materia Medica

基　　金：河南省科技厅自然科学基金项目(004025400)

摘　　要：目的:观察紫金散对小鼠H22肝癌腹水瘤及实体瘤的抑瘤率及量效关系。方法:将昆明小鼠移植H22肝癌细胞后,分为模型组,环磷酰胺组,紫金散低、中、高剂量组,观察紫金散对肝癌腹水瘤及实体瘤的抑瘤率。结果:紫金散3个剂量组对H22小鼠肝癌腹水瘤抑瘤率分别为6.77%,15.59%,14.90%,紫金散3个剂量组对H22小鼠肝癌实体瘤抑瘤率分别为30.8%,38.31%,48.59%。结论:紫金散对H22小鼠肝癌实体瘤有较好的治疗作用。Objective： To observe the rate of Zijin powder in inhibiting H22 mice solid and ascites liver cancer and the relation between quatity and effect. Method： The Kunming roles, transplanted by H22 liver cells, were divided into a model group, a cyclophosphamide group and three group of Zijin powder in high dose, medium dose, and low dose. Then observation was made on the rate of Cancer. Result： The inhibiting rates of Zijin powder of three group （ high dose group, medium dose group and low dose group） for H22 mice solid liver cancer were 30.8%, 38.31% and 48.59% respectivily. The inhibiting rates of three group of Zijin powder （low dose group, medium dose and high dose group） for H22 mice ascites liver cancer were 6.77%, 15.59% and 14.90% respectivily.Conclusion： Zijin powder has better effect on H22 mice solid liver cancer, and its effect is greatly increasing with the increased dosage.

关 键 词：紫金散 小鼠 肝癌 抗肿瘤作用 

分 类 号：R285[医药卫生—中药学]