β_2肾上腺素能受体基因多态性与岳西地区高血压患者血压的关系  

Association between the beta 2 adrenergic receptor polymorphism and blood pressure in YueXi population

作　　者：黄帼[1] 吴涤 张学军[3] 李树浓[1] 徐希平 

机构地区：[1]中山大学病理生理教研室,510080 [2]安徽生物医学研究所 [3]安徽医科大学

出　　处：《中华心血管病杂志》2005年第8期713-716,共4页Chinese Journal of Cardiology

基　　金：安徽省教育厅自然科学基金资助(2004kj210)

摘　　要：目的探讨岳西地区人群β2肾上腺素能受体(ADRB2)基因Arg16Gly多态性与血压相关性。方法用RFLP方法对安徽省岳西地区487例高血压病患者及672例家属的β2肾上腺素能受体基因的Arg16/Gly多态性位点进行了检测,应用了以家系为基础的分析方法,分析了岳西地区成年高血压人群ADRB2多态位点与高血压的相关性。结果在岳西人群中,带有ADRB2Arg16等位基因的高血压病患者的收缩压(P=0.003)和舒张压(P=0.003)水平都较低,遗传对血压的影响更适合于共显性模型。结论ADRB2基因Gly16等位基因与高血压可能存在相关关系。Objective To investigate the association between Argl6Gly polymorphism of β2- adrenergic receptor （ADRB2） gene and blood pressure levels. Methods A total of 487 hypertensive individuals were recruited from YueXi county of Anhui province. 672 patients＇ parents and siblings were also invited to take part in the study and used as genomic control. Blood pressure was measured and a standardized questionnaire regarding social-economic characteristics, general health status, occupational history and life-style and dietary factors was administered for each participant. The ADRB2 Arg16Gly polymorphism was genotyped by using a PCR-Restriction Fragment Length Polymorphism （RFLP） method. The association between the ADRB2 polymorphism and hypertension in hypertensive adults was determined by utilizing a family-based association test analysis. Results In this study population, carriers of the ADRB2 Arg16 allele had lower systolic （ P 〈 0. 01 ） and diastolic （ P 〈 0. 01 ） blood pressure, suggesting that the genetic effect on blood pressure was more likely to fit an additive model. Conclusion Our results suggest a probable association between Arg16Gly polymorphism of ADRB2 gene and hypertension.

关 键 词：高血压 受体 肾上腺素能受体β2 多态性 单核苷酸 Β2肾上腺素能受体 受体基因多态性 高血压病患者 患者血压 肾上腺素能受体基因 Arg16Gly 高血压人群 

分 类 号：R544.1[医药卫生—心血管疾病] R681.02[医药卫生—内科学]