冠心病患者D-二聚体、血小板膜糖蛋白测定及临床意义  

The changes and their clinical significance of D-dimer and platelet glycoprotein in patients with coronary heart disease

作　　者：马建林[1] 王圣[1] 李新明[1] 苏哲坦[1] 李斌[1] 陈关良[1] 林劲[1] 王卫[1] 

机构地区：[1]海南省人民医院心内科,海口570311

出　　处：《中华心血管病杂志》2005年第8期724-726,共3页Chinese Journal of Cardiology

基　　金：海南省自然科学基金资助课题(编号:39812)

摘　　要：目的探讨冠心病(CHD)患者血中D-二聚体(D-dimer)、血小板膜糖蛋白(GP)的变化以及临床意义。方法分别测定20例稳定性心绞痛(SA)患者、48例不稳定性心绞痛(UA)患者、20例正常对照组体内的D-dimer、GP含量,并分析有无冠状动脉事件发生者之间的关系,以及与冠状动脉事件检出的敏感度。结果UA组D-dimer、GP含量与SA组、对照组相比较差异有统计学意义(P<0.01),而SA组与对照组相比均无统计学意义(均P>0.05)。有冠状动脉事件发生者与无冠状动脉事件发生者相比也有统计学意义(P<0.05),D-dimer、GPⅡb、GPⅢa对冠状动脉事件的检出均较为敏感。结论D-dimer、GPⅡb、GPⅢa可作为冠状动脉血栓形成的指标之一,并在一定程度上反映了冠状动脉事件发生的危险性。Objective To explore the changes and their clinical significance of D-dimer and platelet glycoprotein （GP） in patients with coronary heart disease. Methods D-dimer and GP in 20 patients with stable angina （SA group）, 48 patients with unstable angina （UA group）, and 20 control cases were measured. The changes of D-dimer and GP in patients with and without coronary events were compared. The sensitivity of those changes in the diagnosis of coronary events was evaluated. Results There were significant differences of D-dimer and GP between UA group and SA group or control group （P 〈 0. 01 ）, while there was no significant difference between SA group and control group （ P 〉 0. 05 ）. There were also significant differences of D-dimer and GP between patients with coronary events and patients without coronary events（P 〈 0. 05 ）. In the sensitivity test for detecting coronary events, D-dimer and GPⅡ 、 GPⅢa were much more sensitive than other parameters. Conclusions D-dimer and GPⅡb、GPⅢa may be regarded as the indexes of coronary thrombosis and used for predicting the severity of coronary events.

关 键 词：冠状动脉疾病 血小板聚集抑制剂 血小板膜糖蛋白类 D-二聚体 血小板膜糖蛋白 冠心病患者 临床意义 蛋白测定 冠状动脉事件 不稳定性心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]