胎儿生长迟缓胎盘病理检查与病原体检测的对比研究  

TheRelationshipbetwenPlacentalPathologyandCertainPathogensDetectedinParafin┐EmbeddedTisuesinCasesofIntrauterineGrowthRetardation

作　　者：刘伯宁[1] 陶雯琪[1] 刘德莉[1] 孙剑英[1] 

机构地区：[1]上海市第六人民医院妇产病理研究室

出　　处：《中华妇产科杂志》1996年第2期90-92,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的：研究胎儿宫内生长迟缓胎盘病理变化与胎盘石蜡包埋组织有关病原体检测结果的相关性。方法：对１９８６～１９９３年５３例胎儿宫内生长迟缓胎盘进行病理检查，并用ＰＣＲ技术对石蜡包埋的胎盘组织进行弓形体、巨细胞病毒及Ⅱ型单纯疱疹病毒检测。结果：５３例中１９例检出病原体，感染率３５．８５％。胎盘有绒毛炎的１８例中１０例病原体阳性，以绒毛发育迟缓为主要病变的１１例中７例病原体阳性，绒毛间隙炎的３例中２例病原体阳性。胎盘有上述病理性改变者，血行性感染发生率达５９．３８％。结论：本研究显示某些原因不明的胎儿宫内生长迟缓系胎盘血行性感染所致。而绒毛炎、绒毛成熟障碍的形态学变化则提示胎盘的血行性感染。Objective:Tostudytherelationshipbetweenplacentalpathologyandcertainpathogensdetectedinparafin-embeddedplacentaltissuesincasesofintrauterinegrowthretardation(IUGR).Methods:ThePCR-DNAtechniqueswereusedfordeterminationofpathogens,includingtoxoplasma,cytomegalovirusandherpssimplextypeⅡinparafin-embeddedplacentaltissuesfrom53casesofIUGR.Results:Among53casesofIUGR,thepathogensweredetectedin19cases(35.85%).Therelationshipsofpathogensdetectedtoplacentalpathologywereanalyzed.Pathogenswerefoundin10of18placentaswithvilitis,7of11placentaswithvilousmaturationretardedand2of3intervilousspaceinfectionsrespectively.Theincidenceofinfectioninthepathologicalplacentaswas59.38%.Conclusions:ThestudysuggestedthatthehaematogenousinfectionscouldplayimportantrolesinunknowncausesofIUGR.

关 键 词：胎儿生长迟缓 病理学 胎盘 合酶链反应 病原体 

分 类 号：R714.430.2[医药卫生—妇产科学]