甲苯喹哌对豚鼠右心室乳头肌动作电位的作用  

EFFECTS OF TOQUIPIDINE ON ACTION POTENTIAL OF GUINEA PIG PAPILLARY MUSCLES

作　　者：史念慈[1] 周思平[1] 鲁映青[1] 郑平[1] 姚明辉[1] 贺曾佑 

机构地区：[1]上海医科大学基础医学院药理学教研室,扬州制药厂

出　　处：《上海医科大学学报》1996年第1期31-33,共3页Journal of Fudan University(Medical Science)

摘　　要：通过研究新抗心律失常药甲苯喹哌（ｔｏｑｕｉｐｉｄｉｎｅ，Ｔｏｑ）抗心律失常作用的心肌电生理学机制。利用微电极技术观察甲苯喹哌对豚鼠右心室乳头肌动作电位的作用，并与利多卡因进行比较。结果：Ｔｏｑ在１和１０μｍｏｌ／Ｌ时对动作电位各参数无明显影响，但在５０及１００μｍｏｌ／Ｌ时，可明显降低动作电位的Ｖｍａｘ，ＡＰＡ，缩短ＡＰＤ２０，ＡＰＤ５０和ＡＰＤ９０，并明显延长或提高动作电位的ＥＲＰ，ＥＲＰ／ＡＰＤ９０和ＥＲＰ－ＡＰＤ９０利多卡因１μｍｏｌ／Ｌ对动作电位各参数无明显影响。１０和５０μｍｏｌ／Ｌ利多卡因可剂量依赖性降低Ｖｍａｘ，ＡＰＡ，缩短ＡＰＤ２０，ＡＰＤ５０和ＡＰＤ９０。并明显延长ＥＲＰ，ＥＲＰ／ＰＤ９０和ＥＲＰ－ＡＰＤ９０结论：Ｔｏｑ有与利多卡因类似的心肌电生理作用，但其效价强度低于利多卡因。PURPOSE To investigae the effects of toquipidine (Toq), a new antiarrhythmic drug,on action potentials.METHODS Effects of Toq on action potentials of guinea pig papillary muscles were studied by intracellular microelectrodes.RESULTS Toq 1 and 10 μmol/L had no effects on all the parameters of action potentials. But Toq 50 and 100 μmol/L significantly inhibited Vmax, APA, APD20, APD50, APD90, and increased ERP,ERP/APD90 and ERP-APD90. Lidocaine 1μmol/L had no effects action potential. But at 10 and 50 μmol/L, lidocaine dose-dependently inhibited Vmax, APA, APD20, APD50, APD90, and increased ERP,ERP/APD90 and ERP-APD90.CONCLUSIONS Toq had a similar myocardiac electrophysiological effects as lidocaine, but itspotency was lower than that of lidocaine.

关 键 词：甲苯喹哌 乳头肌 动作电位 抗心律失常药 

分 类 号：R972.2[医药卫生—药品] R541.705[医药卫生—药学]