电针对实验性腹痛大鼠脚间核、黑质内P物质含量的影响  

EFFECT OF ELECTROACUPUNCTURE ON SUBSTANCE P CONTENT IN NUCLEUS INTERPEDUNCULARIS AND SUBSTANTIA NIGRAL IN RATS WITH EXPERIMENTAL ABDOMINAL PAIN

作　　者：黄娅林[1] 赵晓蓉[1] 黄显奋[1] 李宽[1] 

机构地区：[1]上海医科大学基础医学院神经生物学教研室,皖南医学院人体解剖学教研室

出　　处：《上海医科大学学报》1996年第1期49-51,共3页Journal of Fudan University(Medical Science)

摘　　要：观察腹痛刺激及电针前后脚间核、黑质内Ｐ物质（ＳＰ）含量的变化。在实验性腹痛大鼠上应用免疫组化方法，结合计算机图象处理。腹膜腔注射醋酸致痛后，脚间核吻外侧区（ＩＰＲＬ）内ＳＰ免疫阳性物质的含量明显减少（Ｐ＜０．０１）；而腹膜腔注射醋酸后再给予电针，ＩＰＲＬ内ＳＰ免疫阳性物质的含量明显增加（Ｐ＜０．０５）。痛刺激促进了ＳＰ从ＩＰＲＬ内释放，在脑内传递痛觉信息。电针可激活痛觉调制活动，抑制ＳＰ释放，出现镇痛效应。中脑黑质内的ＳＰ免疫阳性物质含量在各组无明显差异（Ｐ＞０．０５），提示痛刺激和电针对黑质内ＳＰ含量无明显影响。PURPOSE The change of content of substance P like immunoreactivity was investigated in the nucleus interpeduncularis and substantia nigral of rats with experimentalabdominal pain in EA.METHODS Immnunocytochemical methed.Computer image processing technique.RESULTS The distribution of substance P-like immunoreactivity in the nucleus interpeduncularis decreased significantly following injected peritoneal of acetic acid (P<0.01).After EA,the content of substance P-like immunoreactivity increased significantly (P<0.05). Nosignficant change was found the content of substance P in the subtania nigral.CONCLUSIONS The results suggest that substance P in the interpedunclaris might be related to the abdominal pain and EA.

关 键 词：腹痛 电针 P物质 脚间核 黑质 

分 类 号：R246.1[医药卫生—针灸推拿学]