5种抗菌药物对厌氧菌的体外抗菌活性研究  

Comparative in vitro activities of 5 antimicrobial agents against anaerobes

作　　者：冯萍[1] 汪冰[1] 余汝佳[1] 曾维华[1] 朱淑媛[1] 

机构地区：[1]华西医科大学传染病学教研室

出　　处：《中国抗生素杂志》1996年第1期40-42,共3页Chinese Journal of Antibiotics

摘　　要：测定了罗红霉素、ａｚｉｔｈｒｏｍｙｃｉｎ、头孢西丁、托舒沙星对６０株厌氧菌的体外抗菌活性，并同甲硝唑比较，发现托舒沙星对厌氧菌的体外抗菌活性最好，ＭＩＣ_（５０）和ＭＩＣ_（９０）为０．１２５和２ｍｇ／Ｌ优于甲硝唑（０．２５和１６ｍｇ／Ｌ）；罗红霉素（０．５、１６ｍｇ／Ｌ）与甲硝唑相似，ａｚｉｔｈｒｏｍｙｃｉｎ、头孢西丁的体外抗菌活性比甲硝唑略差，ＭＩＣ_（５０）和ＭＩＣ_（９０）分别为４和３２、２和３２ｍｇ／Ｌ，它们对脆弱拟杆菌的体外抗菌活性优于对其它拟杆菌的体外抗菌活性，对短真杆菌、变形链球菌、普氏消化链球菌等也具有较好的体外抗菌活性。The in vitro activities of roxithromycin,azithromycin, cefoxitin and tosufloxacin were compared with metronidazole against 60 strains of anaerobes. The MIC_(50) (MIC_(90))were as follows:roxithromycin 0. 5(16)mg/L,azithromycin 4(32)mg/L, cefoxitin 2(32)mg/L, tosufloxacin 0.125(2)mg/L and metronidazole 0. 25(16)mg/L respectively.The activities of tosufloxacin and metronidazole against Bacteroides fragilis is higher than those of roxithromycin, azithromycin and cefoxitin. Activities of tosufloxacin, metronidazole and roxithromycin against Bacteroides was observed and they were superior to azithromycin and cefoxitin.Tosufloxacin, roxithromycin, azithromycin and cefoxitin were more active against Gram-positive anaerobes than metronidazole. Results showed that roxithromycin,azithromycin,cefoxitin and tsoufloxacin have good in vitro activities against anaerobes.

关 键 词：厌氧菌 体外 抗菌活性 罗红霉素 AZITHROMYCIN 

分 类 号：R978.1[医药卫生—药品]