不同剂量尿激酶及肝素对不稳定性心绞痛的疗效观察  

A clinical observation on the treatment of unstable angina pectoris by the use of differeat dose of urine kinase and heparin

作　　者：刘建敏[1] 陈丽[1] 

机构地区：[1]安阳市人民医院心脏中心,455000

出　　处：《实用心脑肺血管病杂志》2005年第5期264-267,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨不同剂量尿激酶及低分子、普通肝素在不稳定性心绞痛(UA)治疗中的疗效差异。方法选择UA患者72例,随机分为:A组低剂量尿激酶1·4万IU/kg,总剂量不超过100万IU。B组普通肝素,先是静推5000IU,以后800IU^1000IU/h维持。C组小剂量尿激酶,尿激酶0·5万IU/kg,60分钟内滴完,连续3天。D组低分子肝素,静脉推注低分子肝素30mg然后按60mg皮下注射每12小时一次,共6天。A、C两组均合用低分子肝素。结果C组与A、B组比较,D组与B比较,ST恢复情况好,心脏事件、硝酸盐类用量及心绞痛发作次数均减少有统计学意义,A组与D组比较,无差异。结论在UA患者尤其是自发型心绞痛患者应用小剂量尿激酶溶栓治疗后,可充分达到抑制血小板和抗凝的效果,从而减少心脏事件的发生率,改善患者预后,并与低分子肝素疗效无差异。Objective To evaluate the therapentic effect on the treatment of unstable angina pectorts（UA） by the use of differeat dose urine kinase and heparin. Methods 72 patients with UA were randomly, divided into 4 groups ： group A was given the low dosage urine kinase 14,000IU/kg, total dosage did not exceed 1 milIion IU, group B gave heparin 5000IU by IV push at the beginning and then 800IU/h - 1000IU/h IV infaslon,group C gave urine kinase 500IU/kg by IV drip for an hour and 3 successive days,group D gave low moIecular heparin organize 30mg by IV push and then 60mg by subcutaneous injection Q 12h for six successive days. Results In group C the recovery of ST was better,use of nitrate and fit of angina pectoris or heart attack were more decrease than that in group A and B, but there was no statistically difference between in group A and D. Conclusion After use of urine kninase or low melocular haparin, the heart attack rate of the patients with UA,especialIy spontaneous angina was marked decrease and the outcome was improved.

关 键 词：小剂量尿激酶 肝素 低分子肝素 不稳定性心绞痛 普通肝素 疗效观察 心绞痛患者 心脏事件 尿激酶溶栓 抑制血小板 

分 类 号：R541.4[医药卫生—心血管疾病] R541.405[医药卫生—内科学]