补肾法预防哮喘的变态和非变态反应机理研究  

Study on the Allergic and Non-Allergic Mechanism of the Prevention for Asthma with Kidney-Reinforcing Regimen

作　　者：沈自尹[1] 胡国让[1] 许得盛[1] 陈伟华[1] 张玲娟[1] 

机构地区：[1]上海医科大学中西医结合研究所脏象研究室

出　　处：《中西医结合杂志》1989年第2期82-84,68,共3页

摘　　要：本文在多年采用温阳片预防哮喘的原理研究基础上,进一步阐明温阳片由于能全面影响哮喘发病的变态反应(IgE 反应,介质释放)和非变态反应(免疫调节,β受体功能,内分泌功能)的多个主要环节,从而发挥了多环节、多途径的作用。The onset of asthma involves the non-allergic mechanism as well as the allergic mechanism. Based on the markedly effectiveness in the prevention of the asthmatic attack with Wen Yang(温 阳)Pill[WYP,a prescription of Kidney-reinforcing regimen(KRR)],the authors investigated its mechanism in the endocrinologic and immunologic aspects and found that WYP could regulate the function of the hypothalamus-pituitary-adrenocortical axis and inhibit the seasonal increasement of the serum IgE level in the attack season through the improvement of the function of suppressor T cell.For further study,the authors observed the specific IgE level and the histamine release simultaneously induced by the same allergen the dust mite extraction.A positive relationship was seen between the specific IgE level and the histamine release in their differences before and after the treatment.The histamine inhalation test showed that the PC_(20)value and β-receptor function of the lymphocyte of the controls were furtherly decreased in the anaphase of the attack season,while those of the WYP group were slightly increased in the same phase. The major pathological linkage were not all the same in the asthma patients and these patients had various manifestations.Since WYP could act on the main linkages of the allergic(IgE,mediator release)and non-allergic(immune regulation,β-receptor function,endocrine function)mechanism,it could be available for the asthma patients with the different manifestations and make them get rid of the vicious circle of the asthmatic attack.In the way,it could relieve or suspend the seasonal attack.According to the above data,the authors concluded that KRR(WYP)had a multi-way regulatory effect on the body.

关 键 词：补肾法 哮喘 预防 变态反应 

分 类 号：R562.250.1[医药卫生—呼吸系统]