肾病综合征的辨证分型与红细胞C_3b受体、T淋巴细胞功能的关系  

Study of the Relationship between Typology of Nephrotic Syndrome and RedCell C_3b Receptor,T Cell Function

作　　者：丁培植[1] 李荣[1] 张菊英[2] 张铮铭 张玉芳[2] 

机构地区：[1]浙江医科大学附属儿童医院 [2]杭州市第一人民医院中心实验室

出　　处：《中西医结合杂志》1989年第4期218-219,197,共2页

摘　　要：对39例肾病综合征患儿进行了中医辨证分型及红细胞 C_3b 受体花环率、T淋巴细胞活性 E 花环率测定。结果患儿组分别为10.09±1.49%、18.92±1.45%,明显低于健康组(分别为14.76±1.27%、25.37±1.28),两组对比差异有非常显著性意义(P<0.001);其中脾虚湿困、脾肾阳虚型两种花环率的降低比肝肾阴虚型明显。表明肾病综合征的发病机理与红细胞、T 淋巴细胞的免疫功能低下有关。This paper reports the determined results of rosette rates of red cell C_3b receptor and active rosette(Ea)rates of T Iymphocyte in 39 cases of nephrotic syndrome.Typology of nephrotic syndrome according to TCM differentiation symptoms,all the 39 cases were divided into three types: (1)13 cases of deficiency of Qi(气)of the Spleen with stagnancy of dampness;(2)9 cases of deficiency of Yang(阳)of the Spleen and Kidney;(3)17 cases of deficiency of Yin(阴)of the Liver and Kidney. The results showed that the red cell C_3b receptor rosette rate and Ea rosette rate in 39 cases of nephrotic syndrome were significantly lower than those in the control.The difference between the two groups was very obvious(P<0.001)among the three types.The rosette rates of both in the deficiency of Qi of the Spleen and deficiency of Yang of the Spleen and Kidney were markedly decreased than those in the control(P<0.001).Whereas,the red cell C_3b receptor rosette rate was lower than that in the control(P<0.01),and T cell Ea rosette rate showed no statistical difference (P>0.05)in the deficiency of Yin of the Liver and Kidney.There was a close relationship between the immune dysfunction of red cell and the pathogenesis in nephrotic syndrome.There was markedly relationship between the pathogenesis of deficiency of Yang of the Spleen and Kidney and deficiency of Qi of Spleen with stagnancy of dampness and T cell immune dysfunction.While the Ea level in deficiency of Yin of the Liver and Kidney was closely correlated with the control.Probably this type was nephrotic nephrosis which had been treated with TCM-WM.

关 键 词：肾病综合征 辨证分型 T细胞 

分 类 号：R692.02[医药卫生—泌尿科学]