Protective effect of albumin on lung injury in traumatic/hemorrhagic shock in rats  

作　　者：丁晨彦 陈作兵 郑树森 高原 张匀 赵雪红 倪玲美 

机构地区：[1]The Department of Emergency Surgery,First AffiliatedHospital,College of Medicine,Zhejiang University,Hangzhou310003,China

出　　处：《Chinese Journal of Traumatology》2005年第5期317-320,共4页中华创伤杂志（英文版）

基　　金：ThisstudywassupportedbytheResearchFoundationofChineseMedicineManagementBureau,ZhejiangProvince(No.2004C071)

摘　　要：Objective. To determine the effect of albumin administration on lung injury in traumatic/hemorrhagic shock （T/HS） rats. Methods： Forty-eight adult Sprague-Dawley rats were divided into three groups randomly （ n = 16 in each group） ： Group A, Group B, Group C. In Group A, rats underwent laparotomy without shock. In Group B, rats undergoing T/HS were resuscitated with their blood plus lactated Ringer＇s （twice the volume of shed blood ）. In Group C, rats undergoing T/HS were resuscitated with their shed blood plus additional 3 ml of 5% human albumin. The expression of polymorphonuclear neutrophils CD18/CD11b in jugular vein blood was evaluated. The main lung injury indexes （the activity of myeloperoxidase and lung injury score） were measured. Results： Significant differences of the expression of CD18/11b and the severity degree of lung injury were found between the three groups. （P〈0.05）. The expression of CD18/CD11b and the main lung injury indexes in Group B and Goup C incresed significantly compared with those in Group A （P 〈0.05）. At the same time, the expression of CD18/CD11b and the main lung injury indexes in Group C decreased dramatically, compared with those in Group B （ P 〈0.05 ）. Conclusions ： The infusion of albumin during resuscitation period can protect lungs from injury and decrease the expression of CD18/CD11b in T/HS rats.

关 键 词：ALBUMINS Respiratory distresssyndrome  adult Traumatic/hemorrhagic shock 

分 类 号：R655.3[医药卫生—外科学]