Effect of Dermal Exposure to Paraphenylenediamine and Linear Alkylbenzene Sulphonate in Guinea Pigs  

作　　者：A. K. MATHUR R. B. RAIZADA M. K. SRIVASTAVA A. SINGH 

机构地区：[1]Industrial Toxicology Research Centre, P. B. No. 80, Mahatma Gandhi Marg, Lucknow-226001 (U. P.), India,Industrial Toxicology Research Centre, P. B. No. 80, Mahatma Gandhi Marg, Lucknow-226001 (U. P.), India,Industrial Toxicology Research Centre, P. B. No. 80, Mahatma Gandhi Marg, Lucknow-226001 (U. P.), India,Industrial Toxicology Research Centre, P. B. No. 80, Mahatma Gandhi Marg, Lucknow-226001 (U. P.), India

出　　处：《Biomedical and Environmental Sciences》2005年第4期238-240,共3页生物医学与环境科学（英文版）

摘　　要：To study the effects of paraphenylenediamine （PPD） and linear alkylbenzene sulphonate （LAS） alone and in combination on the skin. Methods Forty-eight guinea pigs were divided equally into 4 groups and exposed to PPD （4 mg/kg）, LAS （12 mg/kg） and PPD （4 mg/kg） plus LAS （12 mg/kg） for 30 days. The biochemical parameters such as acid phosphatase, gtutathione-s-transferase, glutathione peroxidase, glutathione, lipid peroxidafion and histamine contents in exposed skin were estimated. The histopathological examination of the exposed skin was also carried out. Results The skin enzymes, lipid peroxidation, and histamine increased while glutathione decreased in skin. The simultaneously exposed group showed additive toxic effects. The histopathological examination showed severe hyperkeratosis, thickening of collagen fibres and vacuolisation of epidermal cells in PPD plus LAS exposed skin. Conclusion The findings of the present study suggest that simultaneous exposure to PPD and LAS has additive toxic effects.To study the effects of paraphenylenediamine （PPD） and linear alkylbenzene sulphonate （LAS） alone and in combination on the skin. Methods Forty-eight guinea pigs were divided equally into 4 groups and exposed to PPD （4 mg/kg）, LAS （12 mg/kg） and PPD （4 mg/kg） plus LAS （12 mg/kg） for 30 days. The biochemical parameters such as acid phosphatase, gtutathione-s-transferase, glutathione peroxidase, glutathione, lipid peroxidafion and histamine contents in exposed skin were estimated. The histopathological examination of the exposed skin was also carried out. Results The skin enzymes, lipid peroxidation, and histamine increased while glutathione decreased in skin. The simultaneously exposed group showed additive toxic effects. The histopathological examination showed severe hyperkeratosis, thickening of collagen fibres and vacuolisation of epidermal cells in PPD plus LAS exposed skin. Conclusion The findings of the present study suggest that simultaneous exposure to PPD and LAS has additive toxic effects.

关 键 词：DERMAL PARAPHENYLENEDIAMINE Linear alkylbenzene sulphonate ENZYMES HISTOPATHOLOGY 

分 类 号：X78[环境科学与工程—环境工程]