妊娠高血压综合征患者胎盘组织生存素的表达及意义  

Expression of survivin in placenta tissues of patients with pregnancy induced typertension

作　　者：张树泉[1] 訾思华[1] 孟宪玲[1] 孔爱荣[1] 靳卫国[1] 

机构地区：[1]聊城市人民医院,山东聊城252000

出　　处：《山东医药》2005年第24期11-12,共2页Shandong Medical Journal

摘　　要：目的观察妊娠高血压综合征(妊高征)患者胎盘组织中生存素(surv iv in)的表达情况,探讨其在妊高征发病中的作用。方法采用免疫组化SP法检测正常及妊高征孕妇胎盘组织中surv iv in的表达,并采用计算机图像分析系统进行定量分析。结果surv iv in蛋白主要位于绒毛小叶的合体滋养细胞及细胞滋养细胞,也存在于羊膜绒毛层。妊高征组胎盘滋组织surv iv in的平均光密度值为0.324±0.033,且随病情加重而减少,较正常胎盘的0.390±0.042显著降低(P<0.05).结论胎盘组织中surv iv in的减少可能与妊高征的发生发展有关。Objective： To observe the expression of survivin in placenta and to evaluate its role in the pathogenesis of pregnancy induced hypertension（PIH）. Methods：The survivin in normal and PIH placenta was determined by immunohistochemistry. The mean density was determind by image analysis technique. Results： Survivin was mostly found in syncytiotrophoblast, cytotrophoblast and amnio chorion. The strongest imuo reactivity was observed in the syncytiotrophoblast and cytotrophoblast. The mean density of survivin in PIH placenta（0. 324±0. 033）was significantly lower than that in normal placenta（0. 390± 0. 042）, P 〈0. 05. Conclusion：Reduced survivin expression in placenta may have an important role in the pathogensis in PIH.

关 键 词：妊娠高血压综合征 胎盘 生存素 

分 类 号：R714.24[医药卫生—妇产科学]