HLA-A,-B及-DRB1等位基因的多态性与白血病易感性的关联  

Correlation between the polymorphism of HLA-A,-B,and -DRB1 alleles and susceptibility to leukemia

作　　者：周兰霞[1] 赵丽[1] 

机构地区：[1]兰州大学第一医院中心实验室,甘肃兰州730000

出　　处：《细胞与分子免疫学杂志》2005年第5期619-621,共3页Chinese Journal of Cellular and Molecular Immunology

基　　金：甘肃省自然科学基金暨中青年基金项目(No.YS001-A23-020)

摘　　要：目的:探讨甘肃汉族人群中白血病的易感性与HLA基因多态性之间的关联。方法:采用序列特异性寡核苷酸探针杂交技术(PCR-SSO),对57例白血病患者和45例健康对照组进行HLA-A、-B及-DRB1基因分型。结果:在等位基因HLA-A、-B及-DRB1中,白血病患者的HLA-A01、-B38及-DR15基因的基因频率高于正常对照组(P<0.05),而HLA-A11及-DR03基因的基因频率明显下降(P<0.05)。结论:甘肃省汉族人群基因HLA-A01、-B38及-DR15对白血病具有遗传易感作用;而基因HLA-A11和-DR03对白血病具有遗传拮抗作用。AIM： To explore the correlation between the polymorphism of HLA-A. -B and -DRB1 alleles and susceptibility to leukemia in Chinese Han population, Gansu province. METHODS： The polymorphism of HLA-A, -B and -DRB1 alleles in 57 patients with leukemia and 45 normal controls were determined by PCR with sequence-specific oligonucleotide probe （PCR-SSO）. RESULTS： The frequencies of allele HLA-A01, -B38. and -DR15 in patients with leukemia were higher than those in control group （ P 〈 0. 05 ）, while the frequencies of allele HLA-A11 and -DR03 notably decreased （ P 〈 0.05）. CONCLUSION ： HLA-A01. -B38 and -DR15 alleles in Han population, Gansu province seem to contribute to the genetic susceptibility, while HLA-A11 and -DR03 alleles to the genetic resistance, to leukemia.

关 键 词：HLA 白血病 PCR-SSO 多态性 

分 类 号：R392.12[医药卫生—免疫学]