自然周期冷冻胚胎解冻移植临床分析  

A Clinical Analysis of Frozen/thawed Embryo Transfer in Spontaneous Cycles

作　　者：苗本郁[1] 周灿权[1] 方丛[1] 庄广伦[1] 

机构地区：[1]中山大学附属第一医院生殖医学中心,广东广州510080

出　　处：《中山大学学报（医学科学版）》2005年第5期573-577,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省科技攻关基金资助项目(2003A3020305)

摘　　要：【目的】探讨影响自然周期冷冻胚胎解冻移植妊娠率的因素。【方法】回顾性分析本中心2003年1月到2004年1月233个病人进行的268个自然周期冷冻胚胎解冻移植周期,对年龄、子宫内膜厚度和回声类型、LH峰日激素水平以及移植胚胎个数和妊娠率等因素进行分析。【结果】268个周期中58例妊娠,妊娠率21.6%。年龄在妊娠组和未妊娠组间有显著性差异[(30.8±3.0)岁vs(31.9±4.0)岁,P=0.035)]。年龄≤35岁组其LH峰日子宫内膜厚度显著厚于>35岁组(10.2±1.8mmvs9.3±2.0mm,P=0.007)。移植1、2、3个胚胎的妊娠率分别为13.3%、18.2%和23.8%,三组间妊娠率没有显著性差别。LH峰日子宫内膜厚度和类型在妊娠组和未妊娠组间没有显著性差异(P>0.05)。【结论】年龄显著影响自然周期冷冻胚胎移植妊娠率。移植胚胎的个数和子宫内膜的类型及厚度对妊娠率没有显著影响。[Objective]To analyze the impact of a number of factors on the pregnancy rate of frozen/thawed embryo transfer in spontaneous cycles. [Methods]A database was analyzed retrospectively concerning frozen/thawed embryo transfer in spontaneous cycles from January 2003 to January 2004 that covered 268 cycles in 233 patients. The factors investigated were maternal age, endometrial thickness, echogenic pattern, hormone levels of luteinizing hormone （LH） surge day, the number of embryos transferred and pregnancy rate per embryo transfer.[Results]The pregnancies were occurred in 58 cycles of all 268 natural cycles, the pregnancy rate per embryo transfer was 21.6%. The mean age of the patients with pregnancy were statistically significant younger than that of the patients without pregnancy （30.8±3.0 years vs 31.9±4.0 years, P=0.035）. The endometrial thickness on the day of LH surge at the age of less than 35 years was significant thicker than that at the age of more than 35 years （10.2±1.8 mm vs 9.3±2.0 mm, P=0.007）. The pregnancy rates were 13.3%, 18.2%, and 23.8% in the cycle of transferred 1, 2, and 3 embryos, respectively. However, there was no significant difference in these three groups. There was no significant difference of endometrial thickness aad echogenic pattern, between the pregnancy and the non-pregnancy group. [Conclusion ]Our study suggests that the age of female partners can significantly affect the pregnancy rate of frozen/ thawed embryo transfer in spontaneous cycles. The pregnancy rate was not influenced by the number of embryos transferred per cycle, endometrial thickness nor echogenic pattern.

关 键 词：冷冻/解冻胚胎移植 妊娠率 自然周期 年龄 子宫内膜 

分 类 号：R715.9[医药卫生—妇产科学]