高压氧血颈动脉灌注治疗重型颅脑损伤的临床研究  

Clinical study on pouring hyperbaric oxygenation blood into carotid arteries in treatment of severe head injury

作　　者：蔡坤皓[1] 陈东[1] 赵萍[1] 温定国[1] 陈建良[1] 

机构地区：[1]暨南大学医学院第二附属医院,深圳市人民医院神经外科,广州518020

出　　处：《中华创伤杂志》2005年第9期646-648,共3页Chinese Journal of Trauma

基　　金：深圳市科委自然科学基金资助项目(200204015)

摘　　要：目的研究高压氧血颈动脉灌注在重型颅脑损伤治疗中的作用。方法对22例重型颅脑损伤患者于伤后约3.5d行高血氧颈动脉灌注治疗,监测灌注前、中、后的脑组织氧分压(PbtO2)、二氧化碳分压(PbtCO2)、pHbt值变化以及伤后3个月格拉斯哥预后评分(GOS)的情况。结果患者高血氧颈动脉灌注治疗后比治疗前的PbtO2升高(P<0.05)。与对照组相比,患者的PbtO2升高,3个月后的GOS改善(P<0.05)。结论高血氧颈动脉灌注在重型颅脑损伤的早期治疗中起着积极和重要的作用。Objective To study the effect of pouring hyperbaric oxygenation （HBO） blood into carotid arteries in treatment of severe head injury. Methods A total of 22 cases with severe head injury were treated with pouring HBO blood into carotid arteries about 3.5 days after head injury. In the meantime, an observation was done on PbtO2, PbtCO2 and pHbt values before, during and after the treatment as well as Glascow coma scale （GOS） three month after injury. Results After pouring hyperbaric oxygenation blood into carotid arteries, PbtO2 was elevated （ P 〈 0.05 ）. Compared with control, PbtO2 was elevated and GOS improved three months after injury （ P 〈 0.05 ）. Conclusion Pouring hyperbaric oxygenation blood into carotid arteries plays an active and important role in early treatment of severe head injury.

关 键 词：高压氧 脑损伤 颈动脉 重型颅脑损伤 动脉灌注治疗 高血氧 临床研究 颅脑损伤患者 格拉斯哥预后评分 颈动脉灌注 

分 类 号：R651[医药卫生—外科学]