艾滋病合并马尔尼菲青霉病12例  

A clinical analysis of 12 cases of AIDS-associated Pencilliosis marneffei

作　　者：陈劲峰[1] 唐小平[1] 蔡卫平[1] 陈万山[1] 易俊卿[1] 

机构地区：[1]广州市第八人民医院感染科,510060

出　　处：《中华传染病杂志》2005年第3期195-198,共4页Chinese Journal of Infectious Diseases

基　　金：广州市重大科技攻关项目(2001-Z-023-01)

摘　　要：目的通过对12例艾滋病(AIDS)合并马尔尼菲青霉病(PSM)临床资料的分析,提高对该病的认识。方法回顾分析2002年11月至2003年11月收治的12例AIDS合并PSM的住院患者的资料。PSM的确诊依靠培养和病理检查。结果本组患者以反复发热、咳嗽、消瘦、腹泻、贫血、淋巴结肿大,皮肤损害尤其是皮肤坏死性丘疹为临床特点,外周血CD4计数均少于0.1×109/L。结论遇上述情况时应考虑PSM并行相关检查,此对PSM的早期诊断、早期治疗和改善预后有重要意义。本组1例极可能是江西首次发现的AIDS合并PSM。Objective To improve the degree of acquaintance to AIDS associated Pencilliosis marneffei （PSM）. Methods Review and analyze the clinical characteristics and treatment of twelve cases of AIDS-associated PSM hospitalized from November 2002 to November 2003. PSM was diagnosed by culture separation and pathological examination. Results Most of the patients presented with prolonged fever, cough, weight loss. diarrhea, anemia, lymphadenopathy and skin lesions, especially necrotic papular eruptions. All patients had significantly decreased peripheral blood CD4 lymphocyte counts （less than 0. 1 × 10^9/L）. Conclusions Clinical doctors should consider the possibility of PSM when the sufferers have the mentioned symptoms. Culture and pathological examination should be taken as soon as possible. It is important for the successful management and treatment of AIDS -associated PSM to diagnose rapidly and accurately. One of the cases may be the first case of PSM associated with AIDS in Jiangxi Province.

关 键 词：获得性免疫缺陷综合征 青霉属 真菌病 马尔尼菲青霉病 艾滋病 住院患者 AIDS 病理检查 PSM 皮肤坏死性 

分 类 号：R512.91[医药卫生—内科学] R519[医药卫生—临床医学]