升主动脉缩窄术后大鼠动脉瘤形态学研究  

MORPHOLOGICAL STUDY ON ASCENDING AORTIC ANEURYSMS INDUCED BY ASCENDING AORTA BANDING

作　　者：范军[1] 柏树令[1] 曹德寿[1] 朱小兵[1] 汪薇[2] 

机构地区：[1]中国医科大学解剖学教研室 [2]中国医科大学实验技术中心,沈阳110001

出　　处：《解剖学报》2005年第4期442-446,共5页Acta Anatomica Sinica

摘　　要：目的研究升主动脉缩窄术后升主动脉瘤形态学和形成原因.方法将40只Wistar大鼠随机分为对照组和实验组.制备升主动脉缩窄模型,于术后3～5个月取升主动脉,采用光镜、特殊染色及基质金属蛋白酶(MMP-2、MMP-3)免疫组织化学的方法对升主动脉瘤进行观察.结果幼年Wistar大鼠升主动脉缩窄术后3～5个月后产生升主动脉瘤,此模型成瘤率为63.3%,其中夹层动脉瘤成瘤率为36.7%,MMP-2、MMP-3在升主动脉瘤中表达强阳性.结论大鼠升主动脉缩窄术产生升主动脉瘤的机率较高,并呈现MMP-2、MMP-3表达强阳性.Objective To investigate the morphology and the cause of the ascending aortic aneurysm induced by ascending aorta handing. Methods Forty young Wistar rats were divided into two groups： the control group （10 rats） and the experiment group （30 rats）. The rat models induced by ascending aorta handing were made. The ascending aortas were taken after operation in 3-5 months,and special staining and immuohistochemical staining technique were performed and observed under light microscope. Results The ascending aortic aneurysms were induced by ascending aorta handing of the young Wistar rats 3-5 months after operation. The occurrence of the aneurysm is 63.3%, and the occurrence of dissecting aneurysms is 36.7% .The expression of MMP-2 and MMP-3 is strong in the ascending aortic aneurysm. Conclusion The occurrence of ascending aortic induced by handing ascending aorta of the young Wistar rat is high,and the expression of MMP-2 and MMP-3 is strong.

关 键 词：升主动脉缩窄 升主动脉瘤 基质金属蛋白酶 免疫组织化学 大鼠 

分 类 号：R654.3[医药卫生—外科学]