银杏叶提取物对坐骨神经再生的影响  

Experimental study of the extract of Ginkgo Biloba leaves influence on regeneration of sciatic nerve

作　　者：武震[1] 刘晓化[1] 李魁章[1] 曲建波[1] 马龙[1] 王海亮[2] 

机构地区：[1]武警黑龙江总队医院外二科,黑龙江哈尔滨150076 [2]黑龙江中医药大学附属一院

出　　处：《中国骨伤》2005年第8期480-482,共3页China Journal of Orthopaedics and Traumatology

摘　　要：目的:研究银杏叶提取物局部应用对坐骨神经再生的影响。方法:选Wistar大鼠32只,随机分为银杏叶提取物组和对照组。在双目放大镜下切断两组大鼠右侧坐骨神经,于神经损伤处和周围肌肉间隙内注射药物后立即行缝合术。2周后进行坐骨神经功能指数、电生理学和组织形态学观测评定。结果:银杏叶提取物组各项指标均优于对照组,其坐骨神经功能指数的恢复、神经纤维的生长速度及数量明显优于对照组。结论:银杏叶提取物局部应用可有效促进大鼠坐骨神经损伤的早期再生,加快神经再生速度与神经功能恢复。Objective：To study the effect of extract of Ginkgo Biloba leaves（EGB）on the repair of sciatic nerve injury. Methods： Thirty-two Wistar rats were randomly divided into a EGB group and a control group. Under binoculars,the sciatic nerve in the right side of rat was cut off and drugs were injected into the injury points and around the compartment of muscles, then suture was immediately performed. After 2 weeks, the following items as sciatic nerve functional index（SFI）, electrophysiology and histornorphology were determined. Results：EGB group had motor nerve conduction, and showed more nerve fibers, bigger axon diameter than control group. SFI and motor nerve conduction velocity （MNCV） in EGB group were significantly higher than those in control group. Conelusion：EGB could promote regeneration of injured peripheral nerves and speed up the process of nerve regeneration at early stage.

关 键 词：坐骨神经 创伤和损伤 银杏叶提取物 神经再生 坐骨神经再生 WISTAR大鼠 坐骨神经功能指数 坐骨神经损伤 神经功能恢复 局部应用 

分 类 号：R651.3[医药卫生—外科学] R285.5[医药卫生—临床医学]