A New Approach to Ethyl 1-Aroyl/Aroylmethyl-5-methyl-3- methylthiopyrazole-4-carboxylates: High Regioselectivity in Alkylation and Acylation Reactions between N-1 and N-2 of a Pyrazole Derivative  

作　　者：Li Rong WEN Gui Long ZHAO Ming LI Wen Ying QI Xiu Li ZHANG Hua Zheng YANG 

机构地区：[1]College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042 [2]State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071 [3]Ocean Food and Drug Institute, Ocean University of China, Qingdao 266003

出　　处：《Chinese Chemical Letters》2005年第9期1161-1164,共4页中国化学快报（英文版）

基　　金：The project was supported by the Natural Science Foundation of Shandong Province(No.Y2003B01);NNSFC(No.20172031.

摘　　要：Two series, totalizing twelve, of new compounds, ethyl 1-aroyl/aroylmethyl-5-methyl-3- methylthiopyrazole-4-carboxylates 5/6, have been synthesized via highly regioselective acylation and alkylation of ethyl 3-methyl-5-methylthio-1H- pyrazole-4-carboxylate 2a with aroyl chloride 3 and alpha-tosyloxysubstitutedacetophenones 4. Unexpected structures of the product have been unambiguously determined by both X-ray crystallographic analysis and 2D NMR.

关 键 词：PYRAZOLE regioselectivity X-ray crystallographic analysis 2D NMR 

分 类 号：O626.32[理学—有机化学]