阿克拉霉素A固体脂质纳米粒制备工艺研究  

Technology of preparation of aclacinomycin A solid lipid nanoparticle

作　　者：何林[1] 李素华[2] 张丽[1] 孙世明[1] 蒋学华[2] 

机构地区：[1]四川省人民医院药剂科,成都610072 [2]四川大学华西药学院,成都610041

出　　处：《实用医院临床杂志》2005年第4期17-18,共2页Practical Journal of Clinical Medicine

基　　金：四川省科技厅重点科技项目(编号:01SY051-41)

摘　　要：目的为促进固体脂质纳米粒的发展,拓宽阿克拉霉素A(ACM-A)制剂学研究内容。方法采用单因素试验初选阿克拉霉素A固体脂质纳米粒(ACM-SLN)的制备条件,并以正交设计优化了ACM-SLN的处方和制备工艺。结果得到的ACM-SLN的平均粒径为63 nm,平均载药量为(4.47±0.05)%,平均包封率为(89.32±0.91)%。结论以卵磷脂为载体材料制备ACM-SLN工艺简便,重现性好。Objective To prepare aclacinomycin solid lipid nanoparticles （ACM-SLN） so as to develop solid lipid nanoparticles-a novel drug delivery system and broaden the pharmaceutics of aclacinomycin A. Methods The orthogonal design was applied to the optimization of the formula and technology of ACM-SLN based on the monofactor experiments. Results The mean diameter of the resulting ACM-SLN was 63 nm, and the drug loading and entrapment ratio averaged （4.47±0.05）% and （89.32±0.91）%, respectively. Conclusion The technology of preparation of ACM-SLN is practicable and reproducible.

关 键 词：阿克拉霉素A 固体脂质纳米粒 制备工艺 

分 类 号：R943[医药卫生—药剂学] R979.14[医药卫生—药学]