A Mitochondrial Genome Sequence of the Tibetan Antelope(Pantholops hodgsonii)  

作　　者：Shu-Qing Xu Ying-Zhong Yang Jun Zhou Guo-En Jing Yun-Tian Chen Jun Wang Huan-Ming Yang Jian Wang Jun Wu Xiao-Guang Zheng and Ri-Li Ge 

机构地区：[1]Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China [2]Research Center forHigh Altitude Medicine, Qinghai University, Xining 810016, China [3]Kunming Institute of Zoology, ChineseAcademy of Sciences, Kunming 650223, China [4]Graduate School, Chinese Academy of Sciences, Beijing100049, China.

出　　处：《Genomics, Proteomics & Bioinformatics》2005年第1期5-17,共13页基因组蛋白质组与生物信息学报（英文版）

基　　金：This work was supported by Chinese Academy of Sciences(grant to Jun Yu,No.KSCX2一SW一331);National Natural Science Foundation of China fgrant to Ri—Li Ge,No.303931331;Natural Research Foundation of Qinghai(grant to Ri—Li Ge,No.2003一N一120).

摘　　要：To investigate genetic mechanisms of high altitude adaptations of native mammals on the Tibetan Plateau, we compared mitochondrial sequences of the endangered Pantholops hodgsonii with its lowland distant relatives Ovis ames and Capra hircus, as well as other mammals. The complete mitochondrial genome of P. hodgsonii （16,498 bp） revealed a similar gene order as of other mammals. Because of tandem duplications, the control region of P. hodgsonii mitochondrial genome is shorter than those of O. ames and C. hircus, but longer than those of Bos species. Phylogenetic analysis based on alignments of the entire cytochrome b genes suggested that P. hodgsonii is more closely related to O. ames and C. hircus, rather than to species of the Antilopinae subfamily. The estimated divergence time between P. hodgsonii and O. ames is about 2.25 million years ago. Eutther analysis on natural selection indicated that the COXI （cytochrome c oxidase subunit I） gene was under positive selection in P. hodgsonii and Bos grunniens. Considering the same climates and environments shared by these two mammalian species, we proposed that the mitochondrial COXI gene is probably relevant for these native mammals to adapt the high altitude environment unique to the Tibetan Plateau.To investigate genetic mechanisms of high altitude adaptations of native mammals on the Tibetan Plateau, we compared mitochondrial sequences of the endangered Pantholops hodgsonii with its lowland distant relatives Ovis ames and Capra hircus, as well as other mammals. The complete mitochondrial genome of P. hodgsonii （16,498 bp） revealed a similar gene order as of other mammals. Because of tandem duplications, the control region of P. hodgsonii mitochondrial genome is shorter than those of O. ames and C. hircus, but longer than those of Bos species. Phylogenetic analysis based on alignments of the entire cytochrome b genes suggested that P. hodgsonii is more closely related to O. ames and C. hircus, rather than to species of the Antilopinae subfamily. The estimated divergence time between P. hodgsonii and O. ames is about 2.25 million years ago. Eutther analysis on natural selection indicated that the COXI （cytochrome c oxidase subunit I） gene was under positive selection in P. hodgsonii and Bos grunniens. Considering the same climates and environments shared by these two mammalian species, we proposed that the mitochondrial COXI gene is probably relevant for these native mammals to adapt the high altitude environment unique to the Tibetan Plateau.

关 键 词：tibetan antelope mitochondrial genome ADAPTATION COXI 

分 类 号：Q959.842[生物学—动物学]