直接熔融聚合法合成生物降解材料PLEG研究 Ⅳ预聚方式的影响  

Studies on the Direct Synthesis of Biodegradable Material PLEG via Melt Copolymerization IV Influences of Different Prepolymerization Methods

作　　者：汪朝阳[1] 赵耀明[1] 王方[1] 

机构地区：[1]华南理工大学材料学院

出　　处：《合成材料老化与应用》2005年第3期7-10,共4页Synthetic Materials Aging and Application

基　　金：高等学校博士学科点专项科研基金资助课题(98056110)广东省自然科学基金资助项目(980504;020885)

摘　　要：直接以乳酸(LA)单体和聚乙二醇(PEG)为原料,通过直接熔融共聚法,合成了生物降解材料聚乳酸-聚乙二醇(PLEG),用特性粘数[η]、GPC、.FTIR、1HNMR、DSC等手段对其进行了系统的表征,发现不同的预聚方式存在一定的影响,LA和PEG直接进行一步预聚时相对分子质量较高,对药物缓释载体PLEG的合成较为有利。Starting from D, L-lactic acid （D, L-LA） and polyethylene glycol （PEG） with number average relative molecular weight （Mn） 1000, and as feed weight ratio mLA/mPEG=9, under the condition of 165℃, 70Pa, 10h and catalyst quality of SnCl2 （or SnO） mCat,/mLA=0.005, but using different prepolymerization methods, the biodegradable material poly （lactic acid）-polyethylene glycol （PLEG） was directly synthesized via melt polycondensation, and characterized with intrinsic viscosity, GPC, FTIR, ^1H NMR, and DSC. The result of GPC showed that the copolymer＇s weight average relative molecular weight （Mw） of the prepolymerization method was higher when D, L-LA and PEG were simultaneously prepolymerized, and the dispersity （Mw/Mn） was higher too than that of the prepolymerization method when D, L-LA was first prepolymerized and then with PEG together, Therefore, the former was more advantageous for the synthesis of drug delivery carrier PLEG.

关 键 词：聚乳酸-聚乙二醇(PLEG) 直接熔融聚合 生物降解材料 预聚方式 相对分子质量 药物缓释载体 

分 类 号：TQ31[化学工程—高聚物工业]