冠心病患者外周血可溶性细胞间黏附分子-1、血管细胞黏附分子-1、CD18及P选择素检测  

Detect on of serum intercellular adhesion molecule-1,vascular adhesion molecule-1,CD18,and P selectin in patients with coronary heart disease

作　　者：田敏[1] 刘安丽[1] 魏玉静[2] 刘长海[2] 王路[2] 

机构地区：[1]南阳医学高等专科学校基础部,南阳473058 [2]南阳医学高等专科学校第一附属医院心内科,南阳473058

出　　处：《郑州大学学报（医学版）》2005年第5期900-901,共2页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨冠心病患者外周血可溶性细胞间黏附分子-1(sICAM-1)、血管细胞黏附分子-1(sVCAM-1)、CD18及P选择素水平的变化。方法:选择稳定型心绞痛患者(SA组)30例、不稳定型心绞痛患者(UA组)32例、急性心肌梗死患者(AMI组)28例,采用ELISA法检测其外周血血清可溶性P选择素、sICAM-1和sVCAM-1及CD18水平。以年龄相当而无重要冠心病危险因素的正常人50例作为对照。结果:与对照组相比,冠心病患者外周血清sICAM-1、sVCAM-1、CD18及P选择素水平升高,且AMI组各指标水平高于UA组,UA组高于SA组(P均<0.05)。结论:ICAM-1、VCAM-1、CD18及P选择素可能参与了冠心病的发生、发展过程,可作为监测病情的指标。Aim： To explore the changes of serum intercellular adhesion molecule-1 （ sICAM-1 ） , vascular adhesion molecule-1 （sVCAM-1）, CD18, and P-selectin level in patients with coronary heart disease. MethodS： A total of 90 patients with coronary heart disease,including 30 cases of SA,32 cases of UA, and 28 cases of AMI, were subjected to detect the serum levels of sICAM-1, sVCAM-1, CD18 ,and P-selectin using ELISA method. Fifty normal individuals without the major tradition risk factors of coronary heart disease was used as control. Results ： Compared with those of control, the serum levels of the four indexes mentioned above of AMI, UA, and SA groups（ P 〈 0.01 ） were higher. Conclusion： The four indexes mentioned above may involve in the pathogenesis and process of coronary heart disease,and might be an available index that reflexes the sevenity of coronary heart disease.

关 键 词：冠心病 细胞间黏附分子-1 血管细胞黏附分子-1 CD18 P选择素 

分 类 号：R541.4[医药卫生—心血管疾病]