沙丁胺醇与特布他林治疗支气管哮喘和慢性阻塞性肺病的疗效比较  

A Comparative Analysis on the Effect of Two Agonists in Asthma and COPD

作　　者：沈继奋[1] 李承红[1] 李西方[1] 叶舟[1] 夏筱娟[1] 王传海[1] 蔡冬兰 

机构地区：[1]武汉市职工医学院附院内科 [2]武汉市职工医学院肺功能室,430015

出　　处：《药物流行病学杂志》1996年第1期11-12,共2页Chinese Journal of Pharmacoepidemiology

摘　　要：用沙丁胺醇控释剂与特布他林进行对比,共治疗支气管哮喘和慢性阻塞性肺病患者38例。结果显示两组总有效率相似(P>0.05)。用沙丁胺醇或特布他林后30分,10d后与用药前比较,FEV_(1.0)和PEF均有显著改善(P<0.01),但用药后8h,特布他林对FEV_(1.0)和PEF的作用减退,沙丁胺醇仍有疗效(P<0.01)。我们认为两种药物均有显著效果,但对夜间发作的支气管哮喘,应用沙丁胺醇需增加用药的次数,控释剂型有其优越性。8 cases of asthma and COPD were treated with release-controlled salbutamol (VOLMAX) or Bricahyl. The total effective rate were similar (P<0. 05). FEV1 and PEF were significantly improved (P<0. 01) 30 min and 10 days after treatment. However, the effect of Bricanyl abated 8h after administration, while the effect of Salbutamol remained (P<0.01). It is suggested that the above-mentioned B2-agonists are both effective in the treatment of asthma and COPD. When Bricanyl is used for treating asthma during night, it should be administered more frequently or a release-controlled preparation should be used.

关 键 词：沙丁胺醇 特布他林 哮喘 慢性阻塞性肺病 

分 类 号：R562.250.5[医药卫生—呼吸系统] R563.05[医药卫生—内科学]