重组人生长激素对老年大鼠有无牙颌骨吸收的影响  

The effects of recombinant human growth hormone on mandibular bone loss with or without teeth in the ovariectomized rats

作　　者：王旭霞[1] 张君[1] 赵作勤[1] 邢达源[1] 陈磊[1] 

机构地区：[1]山东大学口腔医学院,山东济南250012

出　　处：《上海口腔医学》2005年第4期416-418,共3页Shanghai Journal of Stomatology

基　　金：山东省卫生科技发展计划基金(26010305210213)

摘　　要：目的:探讨重组人生长激素(recombinanthumangrowthhormone,rh-GH)对老年性有牙及无牙颌骨吸收的影响。方法:建立去势大鼠老年骨质疏松模型,拔除大鼠一侧下颌磨牙,次日给予rh-GH1mg·kg-1·d-1皮下注射,连续用药10d;术后8周、12周测量大鼠体重变化,并测定大鼠下颌骨的骨密度、骨矿含量、肌组织量、脂肪组织量;测量指标的组间比较,采用方差分析进行统计学处理。结果:rh-GH治疗组去势大鼠的体重增加,有牙及无牙颌骨密度与治疗前比较,差异有显著性(P<0.05)。结论:重组人生长激素能够增加老年大鼠体重,减缓老年大鼠有牙及无牙颌骨的吸收。PURPOSE： To investigate the effects of recombinant human growth hormone （rh-GH）on mandibular bone loss with or without teeth in the ovariectomized rats. METHODS： Three-month aged ovariectomized rats were utilized as postmenopausal osteoporosis models and all the molars in left mandibles were extracted. After operations, the rats began to receive rh-GH 1mg·kg^-1· d^-1 with subcutaneous injection for ten days.Weight of the rats ,mineral density of the mandibular bone and 3 other parameters were measured at 8＇h week and 12＇h week. The data was analyzed with F and t test. RESULTS： The weight of the rats increased and mandibular bone mineral density of the rats were significantly improved after rh-GH treatment, P〈0.05. CONCLUSION： Rh-GH can increase the weight of the old rats and restore mandibular bone mass in mandibles with or without teeth. Supported by Science and Technology Development Fund of Public Health of Shandong Province （26010305210213）.

关 键 词：重组人生长激素 下颌骨密度 去势大鼠 无牙颌骨吸收 老年大鼠 骨质疏松模型 测量指标 human 脂肪组织量 统计学处理 

分 类 号：R96[医药卫生—药理学]