不同复温方法对兔低温复温时血清肌酸激酶与脂质过氧化物含量的影响  

Effect of different rewarming methods on the contents of crearine kinase and lipid peroxide in serum during rewarming in hypotbermia rabbits

作　　者：丁江舟[1] 李先进[1] 

机构地区：[1]上海海军医学研究所

出　　处：《中华航海医学杂志》1996年第1期44-46,共3页

摘　　要：目的：观察三种复温方法对体温过低兔的效果及低温复温时血清肌酸激酶（ＣＫ）和脂质过氧化物（ＬＰＯ）含量的影响，同时探讨电磁局部高热在复温中的应用价值。方法：随机选择２８只家兔浸于冷水中使其平均直肠温度降至２５．６℃，随后以三种不同方法复温至直肠温度３５℃。结果：复温方法平均耗时为：温水浴法７５分钟，电磁局部高温法８９分钟，自然复温法４７１分钟；血清ＣＫ、ＬＰＯ含量在低体温期增加，复温后上升更加明显。结论：电磁局部高温法是一种简便、快速的复温方法；血清ＣＫ、ＬＰＯ的增加说明体温过低对组织有一定损伤，表现为组织细胞的抗氧化能力减弱。Aim:To observe the effect of three different rewarming methods on the contents of cre- atine kinase(CK)and lipid-peroxide(LPO)in serum during rewarming in hypothermia rabbits,and to verify the usefulness of electromagnetic regional hyperthermia method during rewarming. Methods:28 rabbits were randomly divided into 3 groups. All the animals were cooled by ice water immersion to a stable rectal temperature of25.6℃ and each group of animals was then rewarmed with the following re-warming methods:(1)warm bath(40℃)with trunk immersion but spare the limbs.(2)electromag- netic induced hyperthermia device with the animals placed in the center of a cylindrical electrode.(3)spontaneous rewarming with the animals wrapped up in thermoprotective thick hlanket.Rexults:The mean time required for rectal temperature rewarming to 35℃was 75 min for warm bath,89 min for electromagnetic hyperthermia and 471 min for spontaneous rewarming method.Serum CK,LPO were increased during low body temperat ure period and were found further increased after rewarming. Con- clusion:Electromagnetic regional hyperthermia is a simple,quickaction method for the treatment of immersion hypothermia and it can be carried out easily on the scene;therefore it is considered superior to other methods. The increase of CK and LPO in serum showed that there was tissue injury and de- creased antioxidation capacity of cells during low body temperature period.

关 键 词：体温过低症 复温 肌酸激酶 脂质过氧化物 

分 类 号：R835.205[医药卫生—航空、航天与航海医学]