红花、当归防治支气管哮喘血液流变学及微循环实验研究  

Experimental Studies of Hemorrheological and Microcircular Effects of Hong Hua and Dang Gui on Bronchial Asthma

作　　者：叶丽红[1] 王荣琥[1] 蔡梅芳[1] 魏睦新[1] 许德金[1] 陈志春[2] 段小波[2] 陆伟[2] 严汉英[2] 

机构地区：[1]南京医科大学第一附属医院,210029 [2]南京药物研究所

出　　处：《微循环技术杂志（临床与实验）》1996年第1期43-45,共3页

摘　　要：本实验研究证实:由药物引起的过敏性哮喘豚鼠的血液流变学异常,其全血粘度增高,与正常生理组比较户<0.05,具有显著意义。此外,由乙酰胆碱激发哮喘的大鼠,呈现气管环间平滑肌内微血管收缩,流速减慢,流态异常,血细胞聚集,微循环障碍。在上述动物模型中,使用红花、当归灌胃或气管表面滴药后,能使哮喘豚鼠的全血粘度降低,与哮喘模型组比较户<0.05,具有显著意义。同时,红花、当归及丹参亦可改善哮喘大鼠的气管微循环,使微血管增粗,流速加快,流态恢复正常。本实验为扩大应用活血化瘀药防治哮喘提供了理论依据。The present experiment demonstrated that the blood viscosity of the models of asthma was higher than that of the nomal group (p<0. 05). Moreover,the rats with asthma induced by acetylcholine showed bronchial microvascular constriction and slow blood flow velocity, blood cell aggregation. The hemor-rheological disturbance in guinea-pigs was significantly relieved by Hong Hua or Dang Gui,as compared to models of asthma group(P<0. 05). Meanwhile,the microcircular failure also was lessened with bronchial mi-crocircular distention and blood flow velosity was increased. This study can provide the theoretical basis for the efficacy of Hong Hua and Dang Gui in the treatment of bronchial asthma.

关 键 词：红花 当归 丹参 哮喘 血液流变学 微循环 

分 类 号：R282.710.5[医药卫生—中药学] R259.622.5[医药卫生—中医学]