雌激素对去卵巢大鼠血清血管紧张素转化酶及血管内皮的影响  

The Effect of Estrogen on Serum Angiotensin-converting-enzyme Levels and Vessel Endothelium in Ovariotomized Rats

作　　者：曹源[1] 吴贻全[1] 李玉光[2] 

机构地区：[1]深圳市罗湖医院心内科,广东深圳518001 [2]汕头大学医学院第一附属医院心内科,广东汕头515041

出　　处：《汕头大学医学院学报》2005年第3期132-134,F0002,共4页Journal of Shantou University Medical College

摘　　要：目的:探讨雌激素(E)对去卵巢大鼠(OVX)血清血管紧张素转化酶(ACE)含量及血管内皮的影响。方法:SD雌鼠50只随机分为OVX组、OVX+E组、OVX+NS组、假手术组和正常对照组(各10只)。实验前、后14周分别检测各组血清雌二醇(E2)及ACE含量,28周后在扫描电镜下观察动脉血管内皮细胞(VEC)变化。结果:14周后OVX+E组血清E2升高,ACE降低,具有统计学意义(P<0.01);余4组实验前、后E2与ACE无统计学意义(P>0.05)。OVX+E组、假手术组和正常对照组血清E2与ACE呈负相关;而OVX组和OVX+NS组无此变化。28周后,OVX+E和正常对照组动脉VEC排列整齐;而OVX组VEC排列紊乱。结论:OVX补充E,可通过降低血清ACE水平发挥对动脉VEC的保护作用。Objective： To investigate the effect of estrogen（E）on serum angiotensin-converting-enzyme（ACE）levels and vessel endothelium in ovariotomized rats（OVX）. Methods： Fifty SD female rats were divided into OVX group, OVX＋E group, OVX＋ NS group（all ovariotomized）, sham group and normal control group. Before and at the end of the 14th week, serum ACE and E2 levels were determined. At the end of the 28th week, the changes of vascular endothelial cell（VEC）were assessed under the scanning electron microscope. Results： For the OVX ＋ E group, serum E2 increased and ACE decreased significantly at the end of the 14th week while there were no such changes in other four groups. The serum E2 showed negative correlation with ACE in OVX ＋ E group, sham group and normal control group while there were no such changes in other groups. At the end of the 28th week, the VEC were arranged orderly in OVX ＋ E group and normal control group while arranged disorderly in the OVX group. Conclusion： E supplied to OVX can protect the vessel endothelium through decreasing serum ACE concentration.

关 键 词：雌激素 血清血管紧张素转化酶 血管内皮 

分 类 号：R459.1[医药卫生—治疗学] R54[医药卫生—临床医学]