抑肽酶对体外循环术后血清LDH、CK-MB、LPO变化的影响  

Effect of Aprotinin on Changes of Serum LDH,CK-MB and LPO in CPB Patients

作　　者：鲁尔雄[1] 杨波[1] 李国虎[1] 陈胜喜[1] 周汉槎[1] 袁明道[1] 

机构地区：[1]湖南医科大学附属湘雅医院胸心外科,博士研究生410008

出　　处：《中国胸心血管外科临床杂志》1996年第1期11-13,共3页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

摘　　要：40例简单先心病 CPB 手术病例均分为两组。实验组在 CPB 预充液中一次性加入抑肽酶6万 KIU/kg,对照组不用抑肽酶。于 CPB 前,CPB 后1、4、12、24小时抽桡动脉血测定 LDH、CK-MB、LPO,结果表明:抑肽酶能降低 CPB 术后 LDH、CK-MB、LPO 上升幅度,从而提示具有可能的临床心肌保护作用。Forty patients who underwent CPB surgery were divid- ed into 2 groups (Aprotinin group and control group,20 cas- es each).Blood samples were taken at pre-CPB,post-CPB 1hr,4hr,12hr,24hr to determine the LDH,CK-MB and LPO levels.The results showed that aprotinin can signiri- cantly decrease the increasing levels of LDH,CK-MB and LPO.This suggest that aprotinin may be myoeardio-pretec- tire in CPB patients.

关 键 词：磷酸肌酸激酶 LPO 抑肽酶 体外循环 乳酸脱氢酶 

分 类 号：R654.1[医药卫生—外科学]